INT281277

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Context Info
Confidence 0.41
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 0.93
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Stx2)
Anatomy Link Frequency
monocyte 2
blood 1
neutrophils 1
Stx2 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 54 97.60 Very High Very High Very High
Inflammation 18 5.00 Very Low Very Low Very Low
cytokine 12 5.00 Very Low Very Low Very Low
withdrawal 6 5.00 Very Low Very Low Very Low
Crohn's disease 6 5.00 Very Low Very Low Very Low
Angina 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 42 91.84 High High
Hemolytic Uremic Syndrome 246 86.16 High High
Heart Rate Under Development 30 76.08 Quite High
Thrombotic Microangiopathies 18 56.16 Quite High
Sepsis 18 54.52 Quite High
Cv Unclassified Under Development 6 50.60 Quite High
Endotoxemia 24 47.16 Quite Low
Acute Coronary Syndrome 6 44.88 Quite Low
Thrombosis 6 39.52 Quite Low
Disease 36 33.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stx2 and EHEC-LPS induce tissue factor–positive microparticles
Positive_regulation (induce) of Stx2
1) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0 Pain Relevance 0.06
Co-stimulation with Stx2 and LPS resulted in an additive effect with regard to platelet-monocyte aggregate formation and TF expression on these aggregates, particularly when high shear forces were applied.
Positive_regulation (stimulation) of Stx2 in monocyte
2) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0.52 Pain Relevance 0
Taken together these results show that Stx2, O157LPS and Stx2/LPS induce a significant increase in TF expression, predominantly on platelet-monocyte aggregates, that the combination of Stx2 and LPS had an additive effect on TF-expression on platelet-monocyte aggregates, and that O157LPS was slightly more potent than the other LPS serotypes.


Positive_regulation (combination) of Stx2 in monocyte
3) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0 Pain Relevance 0
Stx2 and EHEC-LPS induce tissue factor–positive microparticles
Positive_regulation (microparticles) of Stx2
4) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0 Pain Relevance 0.06
Stx2, LPS (O157:H7 or O111:B4) or Stx2/LPS were added to whole blood immediately before perfusion through a parallel plate flow chamber.
Positive_regulation (/) of Stx2 in blood
5) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0.20 Pain Relevance 0.15
Stx2 stimulation increased CD11b expression in platelet-bound as well as in platelet-free monocytes whereas only a weak increase was detected in neutrophils in complex with platelets and no increase was seen in platelet-free neutrophils (Figure 3C).
Positive_regulation (stimulation) of Stx2 in neutrophils
6) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0.21 Pain Relevance 0

General Comments

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