INT281282

Context Info Confidence 0.34 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.34 Pain Relevance 0

cell differentiation (Stx2)

Anatomy Link Frequency monocyte 1 platelet 1 Stx2 (Mus musculus)

Pain Link Frequency Relevance Heat agonist 18 5.00 Inflammation 6 5.00 cytokine 4 5.00 withdrawal 2 5.00 Crohn's disease 2 5.00 Angina 2 5.00

Disease Link Frequency Relevance Heat Stress 14 83.20 Hemolytic Uremic Syndrome 82 77.52 Thrombotic Microangiopathies 6 47.52 Sepsis 6 45.88 Cv Unclassified Under Development 2 41.96 Endotoxemia 8 38.52 Acute Coronary Syndrome 2 36.24 Thrombosis 2 30.88 Injury 6 19.76 Heart Rate Under Development 10 12.08

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The additive effect of both Stx2 and LPS was also demonstrated regarding microparticle generation, especially platelet-derived microparticles.

Negative_regulation (effect) of Stx2 in platelet

1) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0.34 Pain Relevance 0

Incubation of whole blood with a combination of Stx2 and LPS (O157:H7LPS or O111:B4LPS) induced a significant increase in platelet-monocyte aggregates as well as platelet-free monocytes expressing TF compared to Stx2 or LPS alone.

Negative_regulation (combination) of Stx2 in monocyte

2) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.