INT281286

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Context Info
Confidence 0.39
First Reported 2009
Last Reported 2009
Negated 2
Speculated 1
Reported most in Body
Documents 1
Total Number 13
Disease Relevance 2.02
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Stx2)
Anatomy Link Frequency
platelet 7
neutrophils 3
monocytes 1
leukocytes 1
blood cells 1
Stx2 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 117 98.84 Very High Very High Very High
withdrawal 13 32.64 Quite Low
Inflammation 39 5.00 Very Low Very Low Very Low
cytokine 26 5.00 Very Low Very Low Very Low
Crohn's disease 13 5.00 Very Low Very Low Very Low
Angina 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 78 98.72 Very High Very High Very High
Hemolytic Uremic Syndrome 533 97.36 Very High Very High Very High
Acute Renal Failure 65 97.32 Very High Very High Very High
Stress 91 93.00 High High
Hypersensitivity 13 76.16 Quite High
Heart Rate Under Development 65 48.80 Quite Low
Endotoxemia 52 5.00 Very Low Very Low Very Low
Thrombocytopenia 39 5.00 Very Low Very Low Very Low
Thrombotic Microangiopathies 39 5.00 Very Low Very Low Very Low
Sepsis 39 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stx2 binds to monocytes and to activated platelets
Stx2 Binding (binds) of in platelets
1) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0 Pain Relevance 0.14
Results shown above indicated that Stx2 alone did not have as profound effect on platelet-leukocyte aggregate formation, platelet or leukocyte activation and TF-positive microparticle generation as LPS, and since this response was mostly demonstrated in monocytes, we examined the ability of Stx2 to bind to platelets, monocytes and neutrophils.
Stx2 Spec (examined) Binding (bind) of in platelet
2) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0.05 Pain Relevance 0.12
Stx2 binding was also examined on purified platelets, monocytes and neutrophils and binding was detected in a similar manner.
Stx2 Binding (binding) of in monocytes
3) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0 Pain Relevance 0
There was no binding of Stx2 to platelet-bound neutrophils and no binding was detected when the primary anti-Stx2 antibody was omitted.


Stx2 Neg (no) Binding (binding) of in neutrophils
4) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0.08 Pain Relevance 0.10
Binding of Stx2 to platelet-leukocyte aggregates or to free (unbound) platelets, monocytes or neutrophils was assayed in whole blood, incubated with Stx2 (200 pg/mL) for 30 min at 37°C and the antibody combinations described above.
Stx2 Binding (Binding) of in neutrophils
5) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0 Pain Relevance 0.03
Binding of Stx2 and O157LPS to platelets and leukocytes
Stx2 Binding (Binding) of in leukocytes
6) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0 Pain Relevance 0.03
In addition, all patients had Stx2 bound to their platelet-free monocytes (median 37%, range 30–41%), platelet-free neutrophils (median 22, range 17–32%) as well as to their unbound-platelets (median 55%, range 39–82%).
Stx2 Binding (bound) of in platelet
7) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0.78 Pain Relevance 0
In the platelet-bound leukocyte population (gate two) the FL1 versus FL2 cytograms were used to estimate the percentage of platelet-leukocyte aggregates with bound TF or Stx2 (Figure 1C).
Stx2 Binding (bound) of in platelet
8) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0.08 Pain Relevance 0
As a control, no binding of the anti-stx2 antibody was detected on blood cells from the three patients with acute renal failure indicating that antibody binding was not due to cell changes related to acute renal failure.


stx2 Neg (no) Binding (binding) of in blood cells associated with acute renal failure
9) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0.85 Pain Relevance 0
Thus a most potent additive effect regarding TF-expression was noted on platelet-monocyte aggregates exposed to Stx2/LPS at high shear rates.


Stx2 Binding (exposed) of in platelet
10) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0.18 Pain Relevance 0.10
Stx2 binding was also examined on purified platelets, monocytes and neutrophils and binding was detected in a similar manner.
Stx2 Binding (binding) of in platelets
11) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0 Pain Relevance 0
Binding of Stx2 and O157LPS to platelets and leukocytes
Stx2 Binding (Binding) of in platelets
12) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0 Pain Relevance 0.03
Stx2 binding was also examined on purified platelets, monocytes and neutrophils and binding was detected in a similar manner.
Stx2 Binding (binding) of in neutrophils
13) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0 Pain Relevance 0

General Comments

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