INT281381

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Context Info
Confidence 0.06
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.13
Pain Relevance 1.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (FSCN1, Gfap) cell proliferation (FSCN1) structural molecule activity (Gfap)
cell motility (FSCN1) extracellular matrix organization (Gfap) protein binding, bridging (FSCN1)
Anatomy Link Frequency
astrocytes 2
dorsal horn 2
FSCN1 (Homo sapiens)
Gfap (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal nerve ligature 114 100.00 Very High Very High Very High
allodynia 72 100.00 Very High Very High Very High
spinal dorsal horn 18 100.00 Very High Very High Very High
Pain 34 98.96 Very High Very High Very High
Dorsal horn 24 98.16 Very High Very High Very High
intrathecal 14 96.32 Very High Very High Very High
Neuropathic pain 48 92.80 High High
Spinal cord 10 5.00 Very Low Very Low Very Low
withdrawal 8 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 122 100.00 Very High Very High Very High
Pain 34 98.96 Very High Very High Very High
Nociception 32 97.92 Very High Very High Very High
Nervous System Injury 32 80.00 Quite High
Injury 6 59.44 Quite High
Hyperalgesia 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similar to our previous observation [26], SNL induced a marked expression of GFAP in the ipsilateral but not the contralateral dorsal horn (Fig. 2B).
SNL Neg (not) Positive_regulation (induced) of Gene_expression (expression) of GFAP in dorsal horn associated with spinal nerve ligature and dorsal horn
1) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736402 Disease Relevance 0.21 Pain Relevance 0.55
SNL induced a significant mechanical allodynia as well as activated SDH neurons indicated by the Fos expression at the early phase and activated astrocytes with the increased expression of GFAP during the late phase of pain, respectively.
SNL Positive_regulation (activated) of Gene_expression (expression) of GFAP in astrocytes associated with pain, allodynia, spinal dorsal horn and spinal nerve ligature
2) Confidence 0.06 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2736402 Disease Relevance 0.91 Pain Relevance 1.43

General Comments

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