INT28145

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Context Info
Confidence 0.48
First Reported 1980
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 26
Total Number 27
Disease Relevance 7.40
Pain Relevance 4.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (PAPPA) peptidase activity (PAPPA) extracellular region (PAPPA)
Anatomy Link Frequency
plasma 18
chest 2
coronary artery 1
plaque 1
eosinophil 1
PAPPA (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 64 100.00 Very High Very High Very High
Bioavailability 20 99.80 Very High Very High Very High
Angina 46 99.72 Very High Very High Very High
lidocaine 2 99.62 Very High Very High Very High
local anesthetic 2 99.42 Very High Very High Very High
antiepileptic Drug 54 99.10 Very High Very High Very High
Somatostatin 11 95.68 Very High Very High Very High
Potency 14 92.96 High High
anticonvulsant 15 92.40 High High
addiction 5 91.96 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 65 100.00 Very High Very High Very High
Coronary Artery Disease 51 99.84 Very High Very High Very High
Atherosclerotic Plaque 12 99.76 Very High Very High Very High
Angina 36 99.72 Very High Very High Very High
Rhinitis 94 99.56 Very High Very High Very High
Epilepsy 16 99.28 Very High Very High Very High
Acute Coronary Syndrome 88 98.72 Very High Very High Very High
Critical Illness 8 98.24 Very High Very High Very High
Death 28 97.80 Very High Very High Very High
Myocardial Infarction 49 97.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Zomepirac is highly bound to plasma protein.
plasma protein Binding (bound) of in plasma
1) Confidence 0.48 Published 1980 Journal J Clin Pharmacol Section Abstract Doc Link 6769977 Disease Relevance 0 Pain Relevance 0.04
Pregnancy-associated plasma protein-A (PAPP-A) was associated with atherosclerotic plaque vulnerability, whereas statin therapy was associated with increased plaque stability.
PAPP-A Binding (associated) of in plaque associated with atherosclerotic plaque
2) Confidence 0.47 Published 2008 Journal Am. J. Cardiol. Section Abstract Doc Link 18157962 Disease Relevance 0.62 Pain Relevance 0.16
Methods for characterising the degree of plasma protein binding in vivo consist of either measuring the concentration of drug at equilibrium in an implanted semipermeable vessel or measuring the relative drug concentrations in two body spaces with different protein content.
plasma protein Binding (binding) of in body
3) Confidence 0.42 Published 1987 Journal Clin Pharmacokinet Section Abstract Doc Link 3301150 Disease Relevance 0.14 Pain Relevance 0.47
Non-steroidal anti-inflammatory drugs (NSAIDs) are distinguished as a class by the high degree to which they bind to plasma protein.
plasma protein Binding (bind) of in plasma associated with inflammation and cinod
4) Confidence 0.42 Published 1987 Journal Clin Pharmacokinet Section Abstract Doc Link 3301150 Disease Relevance 0.17 Pain Relevance 0.36
Many lipophilic drugs are extensively bound to plasma protein but, nonetheless, demonstrate extensive partitioning into liver tissue.
plasma protein Binding (bound) of in plasma
5) Confidence 0.38 Published 1999 Journal Drug Metab. Rev. Section Abstract Doc Link 10335452 Disease Relevance 0.06 Pain Relevance 0.38
Kryptor system was proven to be a rapid, standard method for pregnancy-associated plasma protein A and proform eosinophilic major basic protein (PAPP-A/proMBP) complex detection in coronary artery disease (CAD).
PAPP-A Binding (detection) of in coronary artery associated with rhinitis and coronary artery disease
6) Confidence 0.36 Published 2008 Journal Physiol Res Section Abstract Doc Link 17223728 Disease Relevance 0.94 Pain Relevance 0.15
Combination of PAPP-A/proMBP with cTnI increases their diagnostic efficacy within the early phase of ACS.
PAPP-A Binding (Combination) of associated with acute coronary syndrome
7) Confidence 0.36 Published 2008 Journal Physiol Res Section Abstract Doc Link 17223728 Disease Relevance 1.02 Pain Relevance 0.14
DESIGN AND METHODS: Patients admitted with chest pain and both normal ECG and normal biomarkers were evaluated by serial measurement of PAPP-A.
PAPP-A Binding (measurement) of in chest
8) Confidence 0.36 Published 2010 Journal Clin. Biochem. Section Body Doc Link 20388505 Disease Relevance 0.28 Pain Relevance 0
Physiologically, PAPP-A circulates in a hetero-tetrameric complex consisting of two PAPP-A subunits covalently bound with two subunits of the pro-form of eosinophil major basic protein (proMBP), its endogenous inhibitor (Oxvig C et al. 1993).
PAPP-A Binding (bound) of in eosinophil
9) Confidence 0.36 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688349 Disease Relevance 0.72 Pain Relevance 0
Association of PAPP-A with myocardial damage was assessed in serum samples classified based on serum creatine kinase (CK)-MB or cardiac troponin-T levels.
PAPP-A Binding (Association) of
10) Confidence 0.36 Published 2002 Journal Clin. Biochem. Section Body Doc Link 12493581 Disease Relevance 0.09 Pain Relevance 0
In a multivariable model that included CAD traditional risk factors, ejection fraction, extent of coronary atherosclerosis, prior history of myocardial infarction, prior revascularization, discharge medications, and C-reactive protein, the plasma PAPP-A was found to be significantly associated with the endpoint of future death [adjusted hazard ratio (HR) 5.29; 95% CI 1.27-22.0; P=0.023] and with the endpoint of future death and ACS (adjusted HR 3.56; 95% CI 1.27-10.0; P=0.015), but not with the endpoint of future death and revascularization.
PAPP-A Binding (associated) of in plasma
11) Confidence 0.36 Published 2006 Journal Eur. Heart J. Section Body Doc Link 16717071 Disease Relevance 0.15 Pain Relevance 0
OBJECTIVES: To examine if pregnancy-associated plasma protein-A (PAPP-A) in patients with chest pain, could identify patients at risk for death or myocardial infarction.
PAPP-A Binding (associated) of in chest associated with angina, myocardial infarction and death
12) Confidence 0.36 Published 2010 Journal Clin. Biochem. Section Abstract Doc Link 20388505 Disease Relevance 0.37 Pain Relevance 0.10
CONCLUSIONS: The data are consistent with the conclusion that expression of PAPP-A is enhanced in patients with biochemical evidence of acute coronary syndrome and suggest strongly that demonstration of PAPP-A association with other cardiac markers might be influenced by their relative release dynamics (timing and duration).
PAPP-A Binding (association) of
13) Confidence 0.35 Published 2002 Journal Clin. Biochem. Section Body Doc Link 12493581 Disease Relevance 0.06 Pain Relevance 0
Theoretical relationships are reviewed in order to define quantitatively the impact of plasma protein binding on clearance, half-life, apparent volume of distribution, and the duration and intensity of pharmacological effect.
plasma protein Binding (binding) of in plasma
14) Confidence 0.31 Published 1987 Journal Clin Pharmacokinet Section Abstract Doc Link 3301150 Disease Relevance 0.16 Pain Relevance 0.35
Experimental methods for in vitro and in vivo determination of the degree of plasma protein binding are discussed.
plasma protein Binding (binding) of in plasma
15) Confidence 0.31 Published 1987 Journal Clin Pharmacokinet Section Abstract Doc Link 3301150 Disease Relevance 0.15 Pain Relevance 0.36
Plasma protein binding is discussed as a determinant of the trans-synovial transport of NSAIDs.
Plasma protein Binding (binding) of in Plasma associated with cinod
16) Confidence 0.31 Published 1987 Journal Clin Pharmacokinet Section Abstract Doc Link 3301150 Disease Relevance 0.25 Pain Relevance 0.78
Plasma protein binding of flurbiprofen: enantioselectivity and influence of pathophysiological status.
Plasma protein Binding (binding) of in Plasma
17) Confidence 0.31 Published 1989 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 2724130 Disease Relevance 0.09 Pain Relevance 0.09
Ultrafiltration was used to study the enantioselective binding of R-, S- and racemic flurbiprofen, an arylpropionic acid nonsteroidal anti-inflammatory drug, to human plasma protein in eight normal volunteers.
plasma protein Binding (binding) of in plasma associated with inflammation and cinod
18) Confidence 0.31 Published 1989 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2724130 Disease Relevance 0.10 Pain Relevance 0.10
The experiments carried out in this study with different ligands (homologous saturated fatty acids, indomethacin and lidocaine) show that: 1. ligand hydrophobicity affects the run of the dependence between the free ligand fraction and its total concentration, which confirms the importance of the hydration layer in the drug binding process,2. similar anomalous changes of the free drug fraction are observed not only for drugs interacting with different binding sites on human serum albumin (HSA), i.e. for propofol and indomethacin, but also for basic local anesthetic lidocaine which is known to bind to other plasma protein, alpha-1-acid glycoprotein (AGP).Therefore, the increase of the free drug fraction at its low total concentration does not appear to be an exclusive feature of propofol-HSA system.
plasma protein Binding (bind) of in plasma associated with addiction, lidocaine and local anesthetic
19) Confidence 0.12 Published 2008 Journal Eur J Pharm Sci Section Abstract Doc Link 18644440 Disease Relevance 0 Pain Relevance 0.34
The binding of drugs to the plasma protein also may occur which decreases the amount of free compound that is measured.
plasma protein Binding (binding) of in plasma
20) Confidence 0.06 Published 2004 Journal Bosn J Basic Med Sci Section Abstract Doc Link 15629016 Disease Relevance 0.14 Pain Relevance 0.04

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