INT281469

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Context Info
Confidence 0.72
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.12
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Pten) mitochondrion (Pten) plasma membrane (Pten)
nucleus (Pten) intracellular (Pten) enzyme binding (Pten)
Anatomy Link Frequency
granulocytes 1
neuronal 1
Pten (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 115 97.68 Very High Very High Very High
Serotonin 3 61.68 Quite High
midbrain 15 53.84 Quite High
Dynorphin 6 13.64 Low Low
Ventral tegmentum 8 5.00 Very Low Very Low Very Low
Substantia nigra 8 5.00 Very Low Very Low Very Low
Eae 7 5.00 Very Low Very Low Very Low
monoamine 3 5.00 Very Low Very Low Very Low
dopamine receptor 3 5.00 Very Low Very Low Very Low
Enkephalin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 13 98.44 Very High Very High Very High
Myeloid Leukemia 56 94.96 High High
Death 9 94.44 High High
Myelodysplastic Syndromes 1 85.48 High High
Myeloproliferative Disorder 22 84.28 Quite High
Hematologic Neoplasms 2 82.44 Quite High
Toxicity 1 81.72 Quite High
Disease 13 72.04 Quite High
Leukemia 17 62.16 Quite High
Breast Cancer 2 57.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The demonstration that PTEN/Akt mRNA expression is modulated in response to different apoptotic inducers [7] strongly suggests the association of this pathway with neuronal survival and death.
Transcription (expression) of PTEN in neuronal associated with apoptosis and death
1) Confidence 0.72 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.35 Pain Relevance 0.32
Self-renewal of AML stem cells and leukemic transformation has been previously linked to the lipid phosphatase PTEN (Yilmaz et al., 2006), which is predicted by some target prediction algorithms as a target of miR-29a (Lewis et al., 2005; Grimson et al., 2007); however, PTEN protein and mRNA were expressed at equivalent levels in WT and miR-29a┬ľoverexpressing Mac-1+ Gr-1+ granulocytes (unpublished data).
Transcription (expressed) of PTEN protein in granulocytes associated with myeloid leukemia
2) Confidence 0.04 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.77 Pain Relevance 0

General Comments

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