INT281469

Context Info Confidence 0.72 First Reported 2009 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.12 Pain Relevance 0.32

phosphatase activity (Pten) mitochondrion (Pten) plasma membrane (Pten) nucleus (Pten) intracellular (Pten) enzyme binding (Pten)

Anatomy Link Frequency granulocytes 1 neuronal 1 Pten (Mus musculus)

Pain Link Frequency Relevance Heat Dopamine 115 97.68 Serotonin 3 61.68 midbrain 15 53.84 Dynorphin 6 13.64 Ventral tegmentum 8 5.00 Substantia nigra 8 5.00 Eae 7 5.00 monoamine 3 5.00 dopamine receptor 3 5.00 Enkephalin 2 5.00

Disease Link Frequency Relevance Heat Apoptosis 13 98.44 Myeloid Leukemia 56 94.96 Death 9 94.44 Myelodysplastic Syndromes 1 85.48 Myeloproliferative Disorder 22 84.28 Hematologic Neoplasms 2 82.44 Toxicity 1 81.72 Disease 13 72.04 Leukemia 17 62.16 Breast Cancer 2 57.92

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The demonstration that PTEN/Akt mRNA expression is modulated in response to different apoptotic inducers [7] strongly suggests the association of this pathway with neuronal survival and death.

Transcription (expression) of PTEN in neuronal associated with apoptosis and death

1) Confidence 0.72 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.35 Pain Relevance 0.32

Self-renewal of AML stem cells and leukemic transformation has been previously linked to the lipid phosphatase PTEN (Yilmaz et al., 2006), which is predicted by some target prediction algorithms as a target of miR-29a (Lewis et al., 2005; Grimson et al., 2007); however, PTEN protein and mRNA were expressed at equivalent levels in WT and miR-29a–overexpressing Mac-1+ Gr-1+ granulocytes (unpublished data).

Transcription (expressed) of PTEN protein in granulocytes associated with myeloid leukemia

2) Confidence 0.04 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.77 Pain Relevance 0

General Comments

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