INT281470

Context Info Confidence 0.39 First Reported 2009 Last Reported 2010 Negated 2 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 1.13 Pain Relevance 1.42

phosphatase activity (Pten) mitochondrion (Pten) plasma membrane (Pten) nucleus (Pten) intracellular (Pten) enzyme binding (Pten)

Anatomy Link Frequency DA neurons 2 muscle 2 Pten (Mus musculus)

Pain Link Frequency Relevance Heat Dopamine 230 100.00 Dynorphin 12 72.24 Enkephalin 4 71.68 Nucleus accumbens 2 71.68 Eae 14 69.44 Catecholamine 2 69.20 midbrain 30 66.48 Neurotransmitter 2 53.92 5HT 2 52.88 Substantia nigra 16 46.52

Disease Link Frequency Relevance Heat Apoptosis 76 99.28 Hypertrophy 21 99.08 Targeted Disruption 26 92.52 Lyme Disease 13 50.00 Death 20 43.72 Infection 6 26.04 INFLAMMATION 45 15.68 Neurodegenerative Disease 12 14.32 Obesity 1 13.36 Cancer 16 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

While Pten deletion does not alter DA release, it induces permanent changes in striatal postsynaptic markers

Neg (not) Regulation (alter) of Gene_expression (deletion) of Pten associated with dopamine

1) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.34 Pain Relevance 0.43

Moreover, the DA extraction fraction, calculated as the slope of the no net flux regression line was unchanged in KO mice, suggesting that deletion of Pten in DA neurons did not alter the clearance of extracellular DA by the DA transporter [26].

Neg (not) Regulation (alter) of Gene_expression (deletion) of Pten in DA neurons associated with dopamine

2) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0 Pain Relevance 0.99

Crossing muscle specific PTEN knockouts with the AMPK?

Regulation (specific) of Gene_expression (knockouts) of PTEN in muscle

3) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.41 Pain Relevance 0

In this model, gene expression for phosphatase and tensin homolog (PTEN), which functions to modulate cell survival and proliferation primarily through its downstream effects on AKT1, was shown to be significantly increased (Table 6, right).

Regulation (modulate) of Gene_expression (expression) of PTEN

4) Confidence 0.05 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2771360 Disease Relevance 0.38 Pain Relevance 0

General Comments

This test has worked.