INT281474

Context Info Confidence 0.62 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.35 Pain Relevance 0.32

phosphatase activity (Pten) mitochondrion (Pten) plasma membrane (Pten) nucleus (Pten) intracellular (Pten) enzyme binding (Pten)

Anatomy Link Frequency neuronal 2 Pten (Mus musculus)

Pain Link Frequency Relevance Heat Dopamine 115 97.68 Serotonin 3 62.72 midbrain 15 53.84 Dynorphin 6 13.64 Ventral tegmentum 8 5.00 Substantia nigra 8 5.00 Eae 7 5.00 monoamine 3 5.00 dopamine receptor 3 5.00 Enkephalin 2 5.00

Disease Link Frequency Relevance Heat Apoptosis 10 98.96 Death 9 94.96 Toxicity 1 81.72 Injury 1 48.92 Disease 5 42.28 Cancer 7 5.00 Targeted Disruption 6 5.00 Hypertrophy 3 5.00 Macrocephaly 2 5.00 Glioblastoma 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The demonstration that PTEN/Akt mRNA expression is modulated in response to different apoptotic inducers [7] strongly suggests the association of this pathway with neuronal survival and death.

Regulation (modulated) of Transcription (expression) of PTEN in neuronal associated with apoptosis and death

1) Confidence 0.62 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.35 Pain Relevance 0.32

General Comments

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