INT281477

Context Info Confidence 0.28 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.40 Pain Relevance 0.19

mitochondrion (Pten, Th) cytoplasm (Pten, Th) nucleus (Pten, Th) phosphatase activity (Pten) intracellular (Pten) enzyme binding (Pten)

Anatomy Link Frequency ventral 1 Pten (Mus musculus) Th (Mus musculus)

Pain Link Frequency Relevance Heat Ventral tegmentum 8 89.00 Dopamine 115 66.28 midbrain 15 57.44 Substantia nigra 8 5.00 Eae 7 5.00 Dynorphin 6 5.00 monoamine 3 5.00 Serotonin 3 5.00 dopamine receptor 3 5.00 Enkephalin 2 5.00

Disease Link Frequency Relevance Heat Cancer 7 95.84 Brain Tumor 1 78.64 Targeted Disruption 6 72.16 Hypertrophy 3 64.24 Apoptosis 10 5.00 Death 9 5.00 Disease 5 5.00 Macrocephaly 2 5.00 Glioblastoma 2 5.00 Overdose 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In KO animals the loss of PTEN immunoreactivity in the ventral mesencephalon was associated with increased TH and phospho-AKT staining (Figure 1B).

PTEN Binding (associated) of TH in ventral

1) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.40 Pain Relevance 0.19

General Comments

This test has worked.