INT281479

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Context Info
Confidence 0.23
First Reported 2009
Last Reported 2009
Negated 3
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.40
Pain Relevance 1.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Drd2) signal transduction (Drd2) extracellular region (Penk)
plasma membrane (Drd2) signal transducer activity (Drd2)
Anatomy Link Frequency
neuronal 3
Drd2 (Mus musculus)
Penk (Mus musculus)
Pain Link Frequency Relevance Heat
dopamine receptor 9 99.98 Very High Very High Very High
Dopamine 345 96.56 Very High Very High Very High
midbrain 45 5.00 Very Low Very Low Very Low
Ventral tegmentum 24 5.00 Very Low Very Low Very Low
Substantia nigra 24 5.00 Very Low Very Low Very Low
Eae 21 5.00 Very Low Very Low Very Low
Dynorphin 18 5.00 Very Low Very Low Very Low
monoamine 9 5.00 Very Low Very Low Very Low
Serotonin 9 5.00 Very Low Very Low Very Low
Enkephalin 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophy 9 77.68 Quite High
Cancer 21 57.28 Quite High
Apoptosis 30 5.00 Very Low Very Low Very Low
Death 27 5.00 Very Low Very Low Very Low
Targeted Disruption 18 5.00 Very Low Very Low Very Low
Disease 15 5.00 Very Low Very Low Very Low
Macrocephaly 6 5.00 Very Low Very Low Very Low
Glioblastoma 6 5.00 Very Low Very Low Very Low
Overdose 3 5.00 Very Low Very Low Very Low
Toxicity 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Striatal dopamine receptor D1 (DRD1) and prodynorphin (PDyn) mRNA levels were significantly elevated in KO animals, suggesting an enhancement in neuronal activity associated with the striatonigral projection pathway, while dopamine receptor D2 (DRD2) and preproenkephalin (PPE) mRNA levels remained unchanged.
DRD2 Neg (unchanged) Positive_regulation (unchanged) of preproenkephalin in neuronal associated with dopamine receptor
1) Confidence 0.23 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2736587 Disease Relevance 0.13 Pain Relevance 0.44
Striatal dopamine receptor D1 (DRD1) and prodynorphin (PDyn) mRNA levels were significantly elevated in KO animals, suggesting an enhancement in neuronal activity associated with the striatonigral projection pathway, while dopamine receptor D2 (DRD2) and preproenkephalin (PPE) mRNA levels remained unchanged.
DRD2 Neg (unchanged) Positive_regulation (remained) of preproenkephalin in neuronal associated with dopamine receptor
2) Confidence 0.23 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2736587 Disease Relevance 0.13 Pain Relevance 0.43
Striatal dopamine receptor D1 (DRD1) and prodynorphin (PDyn) mRNA levels were significantly elevated in KO animals, suggesting an enhancement in neuronal activity associated with the striatonigral projection pathway, while dopamine receptor D2 (DRD2) and preproenkephalin (PPE) mRNA levels remained unchanged.
D2 Neg (unchanged) Positive_regulation (remained) of preproenkephalin in neuronal associated with dopamine receptor
3) Confidence 0.20 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2736587 Disease Relevance 0.13 Pain Relevance 0.43

General Comments

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