INT28151

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Context Info
Confidence 0.61
First Reported 1981
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 55
Total Number 58
Disease Relevance 35.09
Pain Relevance 20.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
wrist 4
median nerve 2
canal 1
muscle 1
VWF 1
CTs (Homo sapiens)
Pain Link Frequency Relevance Heat
carpal tunnel syndrome 826 100.00 Very High Very High Very High
rheumatoid arthritis 9 99.12 Very High Very High Very High
Pain 86 94.52 High High
Action potential 4 90.72 High High
Osteoarthritis 4 89.48 High High
Hypoesthesia 1 87.56 High High
Paresthesia 26 86.88 High High
peripheral neuropathy 4 85.12 High High
Analgesic 2 81.84 Quite High
Deep tissue 1 80.80 Quite High
Disease Link Frequency Relevance Heat
Carpal Tunnel Syndrome 932 100.00 Very High Very High Very High
Obesity 38 100.00 Very High Very High Very High
Arthralgia 1 99.92 Very High Very High Very High
Musculoskeletal Disease 4 99.72 Very High Very High Very High
Thyroid Disease 10 99.44 Very High Very High Very High
Injury 40 99.42 Very High Very High Very High
Demyelinating Disease 8 99.28 Very High Very High Very High
Bone Cysts 1 99.28 Very High Very High Very High
Stroke 9 99.20 Very High Very High Very High
Rheumatoid Arthritis 9 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Associated with these differences in threshold, both sensory (p < 0.001) and motor (p < 0.05) refractoriness increased dramatically in CTS patients.
Positive_regulation (increased) of CTS associated with carpal tunnel syndrome
1) Confidence 0.61 Published 2009 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 19909483 Disease Relevance 1.41 Pain Relevance 0.91
However, the most recent systematic literature review on the role of occupation in carpal tunnel syndrome by Palmer et al, found that the regular use of hand-held vibrating tools increased the risk of CTS by more than 2-fold53.
Positive_regulation (increased) of CTS associated with carpal tunnel syndrome and clinical trials and case reports
2) Confidence 0.61 Published 2008 Journal Ulster Med J Section Body Doc Link PMC2397020 Disease Relevance 0.94 Pain Relevance 0.78
However, this recommendation was based on the results of only two studies, hence the low evidence level of this recommendation.24,25 To increase the evidence level of ultrasound treatment for CTS, we need further studies comparing an ultrasound group against a placebo group.
Positive_regulation (increase) of CTS associated with carpal tunnel syndrome
3) Confidence 0.59 Published 2010 Journal Int J Gen Med Section Body Doc Link PMC2934608 Disease Relevance 0.60 Pain Relevance 0.45
CTS was significantly increased for women who used prior hormone replacement therapy (P = .007) or received prior chemotherapy (P = .01).
Positive_regulation (increased) of CTS
4) Confidence 0.55 Published 2009 Journal J. Clin. Oncol. Section Body Doc Link 19752338 Disease Relevance 0.14 Pain Relevance 0
OBJECTIVE: To describe how clinical practice in those who underwent carpal tunnel release (CTR) matched the American Association of Electrodiagnostic Medicine (AAEM) 1993 practice parameters for electrodiagnostic evaluation of carpal tunnel syndrome (CTS).
Positive_regulation (underwent) of carpal tunnel release associated with carpal tunnel syndrome
5) Confidence 0.50 Published 2005 Journal Arch Phys Med Rehabil Section Abstract Doc Link 15640981 Disease Relevance 0.27 Pain Relevance 0.09
RESULTS: Although PBFR increased significantly in all CTS groups when compared to the control group, PBFR in patients who complained of severe pain tended to exceed that in patients with mild to moderate pain.
Positive_regulation (increased) of CTS
6) Confidence 0.50 Published 2009 Journal J Magn Reson Imaging Section Body Doc Link 19388125 Disease Relevance 0.07 Pain Relevance 0
Several studies have noted that the occurrence of CTS is correlated with unhealthy habits and lifestyle39,40.
Positive_regulation (occurrence) of CTS associated with carpal tunnel syndrome
7) Confidence 0.44 Published 2008 Journal Ulster Med J Section Body Doc Link PMC2397020 Disease Relevance 0.87 Pain Relevance 0.65
In a review of 15 cross-sectional studies involving 32 occupational or exposure groups and six-case studies, Hagberg et al noted a high prevalence of CTS in occupations requiring high force and high repetitive manual movements37.
Positive_regulation (prevalence) of CTS associated with carpal tunnel syndrome
8) Confidence 0.44 Published 2008 Journal Ulster Med J Section Body Doc Link PMC2397020 Disease Relevance 0.62 Pain Relevance 0.39
In this study, the presence or absence of recovery in median nerve conduction velocities after weight loss in obese patients was assessed in order to determine whether excess weight or other factors influence the higher prevalence of CTS in obese patients.
Spec (whether) Positive_regulation (prevalence) of CTS in median nerve associated with weight loss, obesity and carpal tunnel syndrome
9) Confidence 0.43 Published 2008 Journal Eur. Neurol. Section Abstract Doc Link 18264014 Disease Relevance 0.81 Pain Relevance 0.36
Based on the above results and on reports of high pressure in Guyon's canal in CTS, ulnar nerve conduction abnormalities may be caused in part by compressive forces progressively transmitted to the canal by increasing pressure in the carpal tunnel with increasing CTS severity.
Positive_regulation (increasing) of CTS in canal associated with cv unclassified under development and carpal tunnel syndrome
10) Confidence 0.43 Published 2008 Journal Muscle Nerve Section Abstract Doc Link 18671289 Disease Relevance 1.26 Pain Relevance 0.85
This finding suggests that factors other than excess body weight may be influential in the higher prevalence of CTS in obese patients.
Positive_regulation (prevalence) of CTS in body
11) Confidence 0.43 Published 2008 Journal Eur. Neurol. Section Body Doc Link 18264014 Disease Relevance 0.12 Pain Relevance 0
METHODS: 206 patients with clinical features suggestive of carpal tunnel syndrome (CTS), including those with known underlying cause of CTS, were screened for thyroid dysfunction.
Positive_regulation (screened) of CTS in thyroid
12) Confidence 0.43 Published 2004 Journal J Clin Rheumatol Section Body Doc Link 17043482 Disease Relevance 0.19 Pain Relevance 0
Overall age-standardised incidence rates of surgically treated CTS (per 100?
Positive_regulation (treated) of CTS associated with carpal tunnel syndrome
13) Confidence 0.41 Published 2009 Journal Occupational and Environmental Medicine Section Body Doc Link PMC2664992 Disease Relevance 0.33 Pain Relevance 0.33
In a review of the records of 169 patients having idiopathic carpal tunnel syndrome (CTS) documented by electrodiagnostic studies, CTS was found to occur significantly more frequently in the dominant hand of both right- and left-handed persons.
Positive_regulation (occur) of CTS associated with carpal tunnel syndrome
14) Confidence 0.40 Published 1981 Journal Arch Phys Med Rehabil Section Abstract Doc Link 7235906 Disease Relevance 0.45 Pain Relevance 0.52
Vibration-induced carpal tunnel syndrome.
Positive_regulation (induced) of carpal tunnel syndrome associated with carpal tunnel syndrome
15) Confidence 0.40 Published 1986 Journal Orthop Rev Section Title Doc Link 3453467 Disease Relevance 0.63 Pain Relevance 0.56
In the majority of cases the cause of CTS is unknown, referred to as idiopathic CTS.
Positive_regulation (cause) of CTS
16) Confidence 0.40 Published 2001 Journal BMC Neurol Section Body Doc Link PMC64540 Disease Relevance 0.77 Pain Relevance 0.33
Our study confirms that frequent flexion, extension and sustained force of the wrist increase the risk of developing CTS.
Positive_regulation (increase) of CTS in wrist associated with carpal tunnel syndrome
17) Confidence 0.40 Published 2007 Journal Hand Surg Section Abstract Doc Link 17613179 Disease Relevance 0.79 Pain Relevance 0.52
Occupations that appear to promote CTS were classified in to three groups: jobs entailing the use of vibratory tools, assembly work and food processing and packing.
Positive_regulation (promote) of CTS associated with carpal tunnel syndrome
18) Confidence 0.40 Published 2007 Journal Brain Nerve Section Abstract Doc Link 18044201 Disease Relevance 1.54 Pain Relevance 1.02
Diabetes, Rheumatoid arthritis, hypothyroidism and pregnancy are known to cause CTS.
Positive_regulation (cause) of CTS associated with diabetes mellitus, thyroid disease, carpal tunnel syndrome and rheumatoid arthritis
19) Confidence 0.40 Published 2007 Journal Brain Nerve Section Abstract Doc Link 18044201 Disease Relevance 1.26 Pain Relevance 0.82
BACKGROUND: Current statistics show that work-related carpal tunnel syndrome (CTS) has been increasing constantly over the last ten years.
Positive_regulation (increasing) of CTS associated with carpal tunnel syndrome
20) Confidence 0.40 Published 2009 Journal Med Lav Section Abstract Doc Link 19601404 Disease Relevance 0.51 Pain Relevance 0.42

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