INT28158

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Context Info
Confidence 0.49
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.34
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Mln (Rattus norvegicus)
Pain Link Frequency Relevance Heat
spastic colon 15 99.80 Very High Very High Very High
Neuropeptide 4 84.60 Quite High
abdominal pain 1 82.00 Quite High
agonist 1 76.96 Quite High
tetrodotoxin 1 69.00 Quite High
Disease Link Frequency Relevance Heat
Diarrhoea 1 99.82 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

11 99.80 Very High Very High Very High
Syndrome 1 95.44 Very High Very High Very High
Functional Bowel Disorder 4 83.68 Quite High
Abdominal Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The response to motilin (10(-6) M) was not only smaller than that to acetylcholine (10(-5) M), it also faded more rapidly with time.
Positive_regulation (smaller) of Gene_expression (response) of motilin
1) Confidence 0.49 Published 1989 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2725711 Disease Relevance 0 Pain Relevance 0.11
In IBS patients circulating motilin levels covaried with total ghrelin levels (r=0.90; p<0.004), octanylated ghrelin (r=0.77; p<0.02) and desoctanylated ghrelin (r=0.69; p<0.04).
Positive_regulation (circulating) of Gene_expression (levels) of motilin associated with spastic colon
2) Confidence 0.40 Published 2010 Journal Peptides Section Abstract Doc Link 20338210 Disease Relevance 0.16 Pain Relevance 0.63
In diarrhoea fasting levels of motilin and PP and postprandial level of PP were increased.
Positive_regulation (increased) of Gene_expression (levels) of motilin associated with diarrhoea
3) Confidence 0.21 Published 1987 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 3477012 Disease Relevance 0.35 Pain Relevance 0.73

General Comments

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