INT281586

Context Info Confidence 0.47 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.06 Pain Relevance 0

nucleus (Trim63) intracellular (Trim63) ligase activity (Trim63) cytoplasm (Trim63)

Anatomy Link Frequency myocardium 1 Trim63 (Rattus norvegicus)

Pain Link Frequency Relevance Heat cytokine 3 40.32 analgesia 1 5.00 nalbuphine 1 5.00 Spinal cord 1 5.00

Disease Link Frequency Relevance Heat Muscular Atrophy 1 55.12 Sepsis 3 37.08 Myocardial Infarction 2 32.28 Heart Rate Under Development 5 5.00 Coronary Heart Disease 1 5.00 Necrosis 1 5.00 Cancer 1 5.00 Pressure Volume 2 Under Development 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It is feasible that this is in part a consequence of the failure of the myocardium to elicit events typically associated with UP-mediated protein degradation, most notably MAFbx/atrogin-1 and MuRF1 mRNA elevation.

Protein_catabolism (degradation) of MuRF1 mRNA in myocardium

1) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0.06 Pain Relevance 0

General Comments

This test has worked.