INT281589

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Context Info
Confidence 0.61
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 6
Disease Relevance 7.91
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Foxo3) nucleus (Foxo3) embryo development (Foxo3)
DNA binding (Foxo3) transcription factor binding (Foxo3) response to stress (Foxo3)
Anatomy Link Frequency
myocardium 2
nucleus 2
Foxo3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 70 92.96 High High
ischemia 5 48.20 Quite Low
anesthesia 15 5.00 Very Low Very Low Very Low
Inflammation 15 5.00 Very Low Very Low Very Low
imagery 10 5.00 Very Low Very Low Very Low
ketamine 5 5.00 Very Low Very Low Very Low
Perioperative pain 5 5.00 Very Low Very Low Very Low
Buprenorphine 5 5.00 Very Low Very Low Very Low
Immobilon 5 5.00 Very Low Very Low Very Low
isoflurane 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 40 99.36 Very High Very High Very High
Myocardial Infarction 392 98.08 Very High Very High Very High
Diabetes Mellitus 275 96.72 Very High Very High Very High
Apoptosis 200 94.48 High High
Fibrosis 60 92.96 High High
Hypertrophy 70 91.76 High High
Cardiovascular Disorder Under Development 10 90.20 High High
Coronary Heart Disease 51 89.56 High High
Cv Unclassified Under Development 5 48.20 Quite Low
Sepsis 3 41.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast unphosphorylated FOXO3a is transported in response to stress into the nucleus where it induces the transcription of FOXO3a-regulated target genes.
Localization (transported) of FOXO3a in nucleus associated with stress
1) Confidence 0.61 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 0.79 Pain Relevance 0
In the GK rat myocardium, Akt- and FOXO3a-phosphorylation was decreased and nuclear localization of FOXO3a was increased concomitantly with increased PTEN protein expression.
Localization (localization) of FOXO3a in myocardium
2) Confidence 0.58 Published 2010 Journal Cardiovasc Diabetol Section Abstract Doc Link PMC2835668 Disease Relevance 1.85 Pain Relevance 0.12
Electrophoretic mobility shift assay was used to assess FOXO3a activity and its nuclear localization.


Localization (localization) of FOXO3a
3) Confidence 0.58 Published 2010 Journal Cardiovasc Diabetol Section Abstract Doc Link PMC2835668 Disease Relevance 1.71 Pain Relevance 0.09
In the GK rat myocardium, Akt- and FOXO3a-phosphorylation was decreased and nuclear localization of FOXO3a was increased concomitantly with increased PTEN protein expression.
Localization (localization) of FOXO3a in myocardium
4) Confidence 0.58 Published 2010 Journal Cardiovasc Diabetol Section Abstract Doc Link PMC2835668 Disease Relevance 1.85 Pain Relevance 0.12
Electrophoretic mobility shift assay was used to assess FOXO3a activity and its nuclear localization.


Localization (localization) of FOXO3a
5) Confidence 0.58 Published 2010 Journal Cardiovasc Diabetol Section Abstract Doc Link PMC2835668 Disease Relevance 1.71 Pain Relevance 0.09
However, when present in the nucleus, Foxo1, Foxo3 and Foxo4 can induce the transcription of the two muscle-specific ubiquitin ligases, MAFbx/atrogin-1 and MuRF1, which are thought responsible for the specific targeting of proteins for subsequent degradation by the proteasome [7], [8].
Localization (present) of Foxo3 in nucleus
6) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0

General Comments

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