INT281594

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Context Info
Confidence 0.67
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 16
Disease Relevance 21.16
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Foxo3) nucleus (Foxo3) embryo development (Foxo3)
DNA binding (Foxo3) transcription factor binding (Foxo3) response to stress (Foxo3)
Anatomy Link Frequency
cardiomyocyte 3
myocardium 2
heart 2
skeletal muscle 1
nucleus 1
Foxo3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 196 99.24 Very High Very High Very High
Inflammation 42 79.76 Quite High
ischemia 14 55.16 Quite High
ketamine 14 55.12 Quite High
anesthesia 42 50.32 Quite High
Perioperative pain 14 39.44 Quite Low
Buprenorphine 14 37.12 Quite Low
imagery 28 5.00 Very Low Very Low Very Low
Immobilon 14 5.00 Very Low Very Low Very Low
isoflurane 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 560 99.92 Very High Very High Very High
Diabetes Mellitus 770 99.68 Very High Very High Very High
Fibrosis 168 99.24 Very High Very High Very High
Myocardial Infarction 1096 99.20 Very High Very High Very High
Stress 112 98.76 Very High Very High Very High
Hypertrophy 196 98.50 Very High Very High Very High
Coronary Heart Disease 142 96.52 Very High Very High Very High
Cardiovascular Disorder Under Development 28 94.04 High High
Sepsis 6 88.40 High High
INFLAMMATION 42 79.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we showed that decreased Akt phosphorylation in the post-infarct GK rat myocardium was associated with a decrease in the phosphorylation of FOXO3a at Akt-preferred Ser253 amino acid.
Phosphorylation (phosphorylation) of FOXO3a in myocardium
1) Confidence 0.67 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 0.83 Pain Relevance 0
In contrast unphosphorylated FOXO3a is transported in response to stress into the nucleus where it induces the transcription of FOXO3a-regulated target genes.
Phosphorylation (unphosphorylated) of FOXO3a in nucleus associated with stress
2) Confidence 0.67 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 0.74 Pain Relevance 0
In the present study our results further showed that another Sirt1- target, FOXO3a was dephosphorylated, possibly due to Akt-kinase dephosphorylation in the diabetic GK rat heart.
Phosphorylation (dephosphorylated) of FOXO3a in heart associated with diabetes mellitus
3) Confidence 0.67 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.54 Pain Relevance 0.08
In GK rats, MI induced an increase in PTEN protein expression, reduced Akt phosphorylation and a concomitant decrease in FOXO3a phosphorylation which might have contributed to the increase in cardiomyocyte apoptosis seen here.
Phosphorylation (phosphorylation) of FOXO3a in cardiomyocyte associated with apoptosis and myocardial infarction
4) Confidence 0.67 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.51 Pain Relevance 0.15
Akt - FOXO3a-dephosphorylation and FOXO3a-activation in diabetic Goto-Kakizaki rats after MI
Phosphorylation (dephosphorylation) of FOXO3a associated with diabetes mellitus and myocardial infarction
5) Confidence 0.66 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 2.12 Pain Relevance 0.03
In the present study our results further showed that another Sirt1- target, FOXO3a was dephosphorylated, possibly due to Akt-kinase dephosphorylation in the diabetic GK rat heart.
Phosphorylation (dephosphorylation) of FOXO3a in heart associated with diabetes mellitus
6) Confidence 0.66 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.61 Pain Relevance 0.08
Akt - FOXO3a-dephosphorylation and FOXO3a-activation in diabetic Goto-Kakizaki rats after MI
Phosphorylation (dephosphorylation) of FOXO3a associated with diabetes mellitus and myocardial infarction
7) Confidence 0.66 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 2.12 Pain Relevance 0.03
Furthermore, while levels of p70 S6K and 4E-BP1 were not examined as part of the previous study, phosphorylation of other downstream targets of AKT kinase activity, namely Foxo1 and Foxo3, were shown to be similarly reduced.
Phosphorylation (phosphorylation) of Foxo3
8) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0
FOXO3a-phosphorylation by Akt results in cytoplasm translocation and ubiquitination and subsequent down regulation of FOXO3a- target genes [43].
Phosphorylation (phosphorylation) of FOXO3a
9) Confidence 0.59 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 0.89 Pain Relevance 0.03
In particular we wanted to investigate whether MI-induced cardiomyocyte hypertrophy, apoptosis and interstitial fibrosis was associated with changes in Akt - FOXO3a phosphorylation, Sirt1 - p53 deacetylation and p38 MAPK phosphorylation.


Phosphorylation (phosphorylation) of FOXO3a in cardiomyocyte associated with fibrosis, hypertrophy, apoptosis and myocardial infarction
10) Confidence 0.51 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.48 Pain Relevance 0.12
The phosphorylation status of Akt-regulated FOXO3a transcription factor was decreased in sham- and MI GK rats and MI Wistar rats (Figure 5C).
Phosphorylation (phosphorylation) of FOXO3a associated with myocardial infarction
11) Confidence 0.51 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.79 Pain Relevance 0
Western blotting was used to study Caspase-3, Bax, Sirt1, acetylation of p53 and phosphorylation of p38, Akt and FOXO3a.
Phosphorylation (phosphorylation) of FOXO3a
12) Confidence 0.51 Published 2010 Journal Cardiovasc Diabetol Section Abstract Doc Link PMC2835668 Disease Relevance 1.49 Pain Relevance 0.09
In particular we wanted to investigate whether MI-induced cardiomyocyte hypertrophy, apoptosis and interstitial fibrosis was associated with changes in Akt - FOXO3a phosphorylation, Sirt1 - p53 deacetylation and p38 MAPK phosphorylation.


Phosphorylation (phosphorylation) of FOXO3a in cardiomyocyte associated with fibrosis, hypertrophy, apoptosis and myocardial infarction
13) Confidence 0.51 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.51 Pain Relevance 0.17
We have recently shown the induction of lipopolysaccharide (LPS)-induced endotoxaemia in rodents to result in the reduction of total AKT protein levels, decreased cytosolic Foxo1 and Foxo3 phosphorylation, and increased levels of MAFbx/atrogin-1 protein and MuRF1 mRNA in fast-twitch skeletal muscle [3], where MAFbx/atrogin-1 and MuRF1 are considered important in the development of skeletal muscle proteolysis during catabolic events [4]–[6].
Phosphorylation (phosphorylation) of Foxo3 in skeletal muscle
14) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0.17 Pain Relevance 0
FOXO3a transcription factor is negatively regulated by Akt, and in the absence of Akt-mediated phosphorylation FOXO3a has been shown to induce the expression of genes implicated in the apoptotic process [20].
Phosphorylation (phosphorylation) of FOXO3a associated with apoptosis
15) Confidence 0.45 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.47 Pain Relevance 0.06
In the GK rat myocardium, Akt- and FOXO3a-phosphorylation was decreased and nuclear localization of FOXO3a was increased concomitantly with increased PTEN protein expression.
Phosphorylation (phosphorylation) of FOXO3a in myocardium
16) Confidence 0.45 Published 2010 Journal Cardiovasc Diabetol Section Abstract Doc Link PMC2835668 Disease Relevance 1.90 Pain Relevance 0.12

General Comments

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