INT281596

Context Info Confidence 0.19 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.18 Pain Relevance 0

cytosol (Foxo1) nucleus (Foxo1) DNA binding (Foxo1) cytoplasm (Foxo1)

Anatomy Link Frequency AtT20 1 Foxo1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat antagonist 5 5.00 cytokine 3 5.00 anesthesia 2 5.00 nalbuphine 1 5.00 Central nervous system 1 5.00 Spinal cord 1 5.00 analgesia 1 5.00 addiction 1 5.00 Hippocampus 1 5.00

Disease Link Frequency Relevance Heat Aids-related Complex 22 67.60 Targeted Disruption 9 61.12 Body Weight 17 5.00 Heart Rate Under Development 5 5.00 Obesity 5 5.00 Appetite Loss 5 5.00 Weight Gain 4 5.00 Sepsis 3 5.00 Decapitation 2 5.00 Aging 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Furthermore, while levels of p70 S6K and 4E-BP1 were not examined as part of the previous study, phosphorylation of other downstream targets of AKT kinase activity, namely Foxo1 and Foxo3, were shown to be similarly reduced.

Regulation (targets) of Foxo1

1) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0

AtT20 cells express Sirt1 (Figure S1B), POMC, and several key transcription factors involved in POMC regulation such as Stat3 and FoxO1 (data not shown).

Regulation (regulation) of FoxO1 in AtT20

2) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.18 Pain Relevance 0

General Comments

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