INT281596

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Context Info
Confidence 0.19
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.18
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Foxo1) nucleus (Foxo1) DNA binding (Foxo1)
cytoplasm (Foxo1)
Anatomy Link Frequency
AtT20 1
Foxo1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 5 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
nalbuphine 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
analgesia 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Hippocampus 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aids-related Complex 22 67.60 Quite High
Targeted Disruption 9 61.12 Quite High
Body Weight 17 5.00 Very Low Very Low Very Low
Heart Rate Under Development 5 5.00 Very Low Very Low Very Low
Obesity 5 5.00 Very Low Very Low Very Low
Appetite Loss 5 5.00 Very Low Very Low Very Low
Weight Gain 4 5.00 Very Low Very Low Very Low
Sepsis 3 5.00 Very Low Very Low Very Low
Decapitation 2 5.00 Very Low Very Low Very Low
Aging 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, while levels of p70 S6K and 4E-BP1 were not examined as part of the previous study, phosphorylation of other downstream targets of AKT kinase activity, namely Foxo1 and Foxo3, were shown to be similarly reduced.
Regulation (targets) of Foxo1
1) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0
AtT20 cells express Sirt1 (Figure S1B), POMC, and several key transcription factors involved in POMC regulation such as Stat3 and FoxO1 (data not shown).
Regulation (regulation) of FoxO1 in AtT20
2) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.18 Pain Relevance 0

General Comments

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