INT281598

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Context Info
Confidence 0.48
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 4.26
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Foxo3) nucleus (Foxo3) embryo development (Foxo3)
DNA binding (Foxo3) transcription factor binding (Foxo3) response to stress (Foxo3)
Anatomy Link Frequency
myocardium 4
cardiomyocyte 2
Foxo3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 42 94.92 High High
Inflammation 9 80.24 Quite High
ischemia 3 34.56 Quite Low
anesthesia 9 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
Perioperative pain 3 5.00 Very Low Very Low Very Low
Buprenorphine 3 5.00 Very Low Very Low Very Low
Immobilon 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 236 98.10 Very High Very High Very High
Diabetes Mellitus 165 97.88 Very High Very High Very High
Apoptosis 120 97.48 Very High Very High Very High
Fibrosis 36 94.92 High High
Hypertrophy 42 93.60 High High
Stress 24 91.12 High High
INFLAMMATION 9 80.24 Quite High
Cardiovascular Disorder Under Development 6 77.48 Quite High
Coronary Heart Disease 31 75.92 Quite High
Hypoxia 3 37.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we showed that decreased Akt phosphorylation in the post-infarct GK rat myocardium was associated with a decrease in the phosphorylation of FOXO3a at Akt-preferred Ser253 amino acid.
Negative_regulation (decrease) of Phosphorylation (phosphorylation) of FOXO3a in myocardium
1) Confidence 0.48 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 0.84 Pain Relevance 0
Furthermore, while levels of p70 S6K and 4E-BP1 were not examined as part of the previous study, phosphorylation of other downstream targets of AKT kinase activity, namely Foxo1 and Foxo3, were shown to be similarly reduced.
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of Foxo3
2) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0
In GK rats, MI induced an increase in PTEN protein expression, reduced Akt phosphorylation and a concomitant decrease in FOXO3a phosphorylation which might have contributed to the increase in cardiomyocyte apoptosis seen here.
Negative_regulation (decrease) of Phosphorylation (phosphorylation) of FOXO3a in cardiomyocyte associated with apoptosis and myocardial infarction
3) Confidence 0.35 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.51 Pain Relevance 0.16
In the GK rat myocardium, Akt- and FOXO3a-phosphorylation was decreased and nuclear localization of FOXO3a was increased concomitantly with increased PTEN protein expression.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of FOXO3a in myocardium
4) Confidence 0.31 Published 2010 Journal Cardiovasc Diabetol Section Abstract Doc Link PMC2835668 Disease Relevance 1.91 Pain Relevance 0.12

General Comments

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