INT281605

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Context Info
Confidence 0.50
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.35
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Foxo3) nucleus (Foxo3) embryo development (Foxo3)
DNA binding (Foxo3) transcription factor binding (Foxo3) response to stress (Foxo3)
Anatomy Link Frequency
heart 1
Foxo3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 28 80.44 Quite High
ischemia 2 51.00 Quite High
anesthesia 6 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Perioperative pain 2 5.00 Very Low Very Low Very Low
Buprenorphine 2 5.00 Very Low Very Low Very Low
Immobilon 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 110 97.00 Very High Very High Very High
Apoptosis 80 95.76 Very High Very High Very High
Stress 16 93.04 High High
Coronary Heart Disease 21 92.36 High High
Hypertrophy 28 88.12 High High
Myocardial Infarction 158 85.68 High High
Fibrosis 24 80.44 Quite High
Sprains And Strains 6 74.32 Quite High
Ventricular Remodeling 2 55.60 Quite High
Cv Unclassified Under Development 2 51.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
FOXO3a-phosphorylation by Akt results in cytoplasm translocation and ubiquitination and subsequent down regulation of FOXO3a- target genes [43].
Regulation (regulation) of FOXO3a
1) Confidence 0.50 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 0.81 Pain Relevance 0.03
In the present study our results further showed that another Sirt1- target, FOXO3a was dephosphorylated, possibly due to Akt-kinase dephosphorylation in the diabetic GK rat heart.
Regulation (target) of FOXO3a in heart associated with diabetes mellitus
2) Confidence 0.22 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.55 Pain Relevance 0.08
Furthermore, while levels of p70 S6K and 4E-BP1 were not examined as part of the previous study, phosphorylation of other downstream targets of AKT kinase activity, namely Foxo1 and Foxo3, were shown to be similarly reduced.
Regulation (targets) of Foxo3
3) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0

General Comments

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