INT281624

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Context Info
Confidence 0.58
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 9
Disease Relevance 8.00
Pain Relevance 2.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
LS174T 2
lymph nodes 1
colon 1
lung 1
Tag (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 448 96.74 Very High Very High Very High
positron emission tomography 312 96.46 Very High Very High Very High
anesthesia 80 77.20 Quite High
isoflurane 40 76.76 Quite High
ketamine 48 48.40 Quite Low
Inflammation 8 42.08 Quite Low
endometriosis 6 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Taxol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 226 100.00 Very High Very High Very High
Adenocarcinoma 43 99.96 Very High Very High Very High
Cancer 698 99.80 Very High Very High Very High
Metastasis 9 96.20 Very High Very High Very High
Disease 38 94.12 High High
Hereditary Nonpolyposis Colorectal Neoplasms 61 91.64 High High
Microsatellite Instability 41 90.48 High High
Familial Adenomatous Polyposis 46 82.24 Quite High
Lewis Lung Carcinoma 8 43.12 Quite Low
INFLAMMATION 9 42.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, the strong expression of JCV T-Ag in the nuclei of most of these tumors implicates this oncogenic virus in the genesis of CRC in young people, including those with DNA MMR defects.


Gene_expression (expression) of T-Ag associated with cancer and colon cancer
1) Confidence 0.58 Published 2007 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2736982 Disease Relevance 0.94 Pain Relevance 0
Such overexpression of TAG-72 is noted in up to approximately 90% of these various adenocarcinomas [24].
Gene_expression (overexpression) of TAG-72 associated with adenocarcinoma
2) Confidence 0.10 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2924340 Disease Relevance 0.94 Pain Relevance 0.25
In that regard, tumor-associated glycoprotein-72 (TAG-72) is a mucin-like glycoprotein complex that is overexpressed by many adenocarcinomas, including colorectal, pancreatic, gastric, esophageal, ovarian, endometrial, breast, prostate, and lung [22,24-27].
Gene_expression (overexpressed) of TAG-72 in lung associated with adenocarcinoma and cancer
3) Confidence 0.10 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2924340 Disease Relevance 0.88 Pain Relevance 0.34
In xenograft mice bearing subcutaneous tumor implants of the TAG-72-expressing human colon adenocarcinoma cell line, LS174T [27-29], anti-TAG-72 monoclonal antibodies have been shown to accumulate up to 18-fold higher in LS174T tumor implants than in normal tissues [25,30,31].
Gene_expression (expressing) of TAG-72 in LS174T associated with cancer and colon cancer
4) Confidence 0.08 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2924340 Disease Relevance 1.04 Pain Relevance 0.19
In xenograft mice bearing subcutaneous tumor implants of the TAG-72-expressing human colon adenocarcinoma cell line, LS174T [27-29], anti-TAG-72 monoclonal antibodies have been shown to accumulate up to 18-fold higher in LS174T tumor implants than in normal tissues [25,30,31].
Gene_expression (expressing) of TAG-72 in LS174T associated with cancer and colon cancer
5) Confidence 0.08 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2924340 Disease Relevance 1.06 Pain Relevance 0.19
Clearly, a PET-based imaging approach that utilizes 124I-HuCC49deltaCH2 is feasible and could potentially have a significant impact upon the current management of colorectal cancer and other TAG-72 antigen-expressing adenocarcinomas.
Gene_expression (expressing) of TAG-72 associated with adenocarcinoma, colon cancer, positron emission tomography and imagery
6) Confidence 0.08 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2924340 Disease Relevance 0.54 Pain Relevance 0.64
Subcutaneous tumor implants of LS174T colon adenocarcinoma cells, which express TAG-72 antigen, were grown on athymic Nu/Nu nude mice as the xenograft model.
Gene_expression (express) of TAG-72 in colon associated with cancer and colon cancer
7) Confidence 0.08 Published 2010 Journal World J Surg Oncol Section Abstract Doc Link PMC2924340 Disease Relevance 0.76 Pain Relevance 0.46
Such an approach that utilizes PET-based imaging in conjunction with 124I-HuCC49deltaCH2 is clinically feasible and could potentially have a significant impact upon the current management of colorectal cancer, as well as upon other TAG-72 antigen-expressing adenocarcinomas.
Gene_expression (expressing) of TAG-72 associated with adenocarcinoma, colon cancer, positron emission tomography and imagery
8) Confidence 0.08 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2924340 Disease Relevance 0.64 Pain Relevance 0.19
Over the last 25 years, our group at The Ohio State University, as well as others, have evaluated a variety of radioiodine labeled anti-TAG-72 monoclonal antibodies for tumor-specific antigen targeting at the time of surgery for known primary, recurrent, and metastatic disease, as well as for targeting occult disease and affected lymph nodes in colorectal cancer patients [22,24,32-59].
Gene_expression (antibodies) of TAG-72 in lymph nodes associated with cancer, colon cancer, disease and metastasis
9) Confidence 0.07 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2924340 Disease Relevance 1.19 Pain Relevance 0.15

General Comments

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