INT28164

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Context Info
Confidence 0.60
First Reported 1983
Last Reported 2010
Negated 1
Speculated 7
Reported most in Body
Documents 25
Total Number 33
Disease Relevance 12.76
Pain Relevance 5.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ALOX5) nuclear envelope (ALOX5) small molecule metabolic process (ALOX5)
oxidoreductase activity (ALOX5) nucleus (ALOX5) cytoplasm (ALOX5)
Anatomy Link Frequency
chondrocytes 5
platelets 3
osteoblasts 2
polymorphonuclear leucocytes 2
internal 1
ALOX5 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 65 100.00 Very High Very High Very High
aspirin 42 100.00 Very High Very High Very High
COX2 5 99.98 Very High Very High Very High
cOX1 2 99.98 Very High Very High Very High
Osteoarthritis 564 99.60 Very High Very High Very High
Inflammation 210 99.44 Very High Very High Very High
agonist 42 99.42 Very High Very High Very High
Action potential 2 98.28 Very High Very High Very High
COX-2 inhibitor 33 97.24 Very High Very High Very High
tolerance 1 93.20 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 287 100.00 Very High Very High Very High
Death 119 100.00 Very High Very High Very High
Osteoarthritis 598 99.60 Very High Very High Very High
Asthma 107 99.32 Very High Very High Very High
Cancer 118 99.08 Very High Very High Very High
Injury 4 98.88 Very High Very High Very High
Atherosclerosis 43 98.84 Very High Very High Very High
Disease 62 96.16 Very High Very High Very High
Apoptosis 163 96.04 Very High Very High Very High
Myocardial Infarction 20 95.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We examined whether 5-lipoxygenase (5-LO), the key enzyme involved in biosynthesis of leukotrienes is a possible target for the spices.
Spec (possible) Regulation (target) of 5-lipoxygenase
1) Confidence 0.60 Published 2004 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 15120715 Disease Relevance 0 Pain Relevance 0.14
We examined whether 5-lipoxygenase (5-LO), the key enzyme involved in biosynthesis of leukotrienes is a possible target for the spices.
Spec (possible) Regulation (target) of 5-LO
2) Confidence 0.54 Published 2004 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 15120715 Disease Relevance 0 Pain Relevance 0.14
One such combination involves the 5-lipoxygenase
Regulation (involves) of 5-lipoxygenase
3) Confidence 0.44 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 1.30 Pain Relevance 0.12
These data suggest that there may be differential effects of genes in a common pathway on several vascular beds through diverse inflammatory mechanisms (based upon the effects of lipoxygenase pathway SNPs on subclinical atherosclerosis and on markers of inflammation (CRP, E-selectin, ICAM-1) and aspects of calcification.
Regulation (effects) of lipoxygenase associated with calcification, inflammation and atherosclerosis
4) Confidence 0.43 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2878676 Disease Relevance 1.32 Pain Relevance 0.10
Salicylate fails to prevent the inhibitory effect of 5,8,11,14-eicosatetraynoic acid on human platelet cyclo-oxygenase and lipoxygenase activities.
Regulation (effect) of lipoxygenase in platelet associated with aspirin
5) Confidence 0.35 Published 1983 Journal Biochim. Biophys. Acta Section Title Doc Link 6411131 Disease Relevance 0.08 Pain Relevance 0.18
The effect of orpanoxin, a nonsteroidal anti-inflammatory drug, on cyclo-oxygenase and lipoxygenase activity in human polymorphonuclear leucocytes (PMNL) and platelets was studied ex vivo to see if lipoxygenase inhibition contributed to orpanoxin's mechanism of action. 2.
Regulation (effect) of lipoxygenase in polymorphonuclear leucocytes associated with inflammation and cinod
6) Confidence 0.33 Published 1988 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 3152163 Disease Relevance 0.10 Pain Relevance 0.10
A more internal locus of control (LoC) is generally seen as desirable, provided it is matched by competence and opportunity so that the person is able to successfully experience the sense of personal control and responsibility [20].
Regulation (control) of LoC in internal
7) Confidence 0.27 Published 2008 Journal BMC Public Health Section Body Doc Link PMC2442069 Disease Relevance 0.11 Pain Relevance 0
Some reports have suggested the possible involvement of the 5-lipoxygenase gene (ALOX5) in AIA.
Spec (possible) Regulation (involvement) of 5-lipoxygenase associated with asthma
8) Confidence 0.26 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687575 Disease Relevance 0.58 Pain Relevance 0.11
Hence emphasis was focused on quantification of structure-activity relationship, with a view to delineating the influence of key COX-2/LOX-5 activity, to explore structural insights to aid the designing of safer dual inhibitors.
Regulation (influence) of LOX-5
9) Confidence 0.26 Published 2006 Journal J Pharm Biomed Anal Section Abstract Doc Link 16781106 Disease Relevance 0.50 Pain Relevance 0.25
The effects of D-penicillamine, sodium aurothiomalate, indomethacin, timegadine and tolfenamic acid on the lipoxygenase and cyclo-oxygenase pathways of arachidonic acid metabolism were studied in human polymorphonuclear leukocytes (PMNs) in vitro.
Regulation (effects) of lipoxygenase in polymorphonuclear leukocytes
10) Confidence 0.23 Published 1988 Journal Agents Actions Section Abstract Doc Link 2845746 Disease Relevance 0.07 Pain Relevance 0.15
In the present study, we investigated the effects of HNE on COX-2/mPGES-1 and 5-LOX pathways regulation in human OA chondrocytes.
Spec (investigated) Regulation (regulation) of 5-LOX in chondrocytes associated with osteoarthritis
11) Confidence 0.19 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.64 Pain Relevance 0.31
Thereafter, we explored 5-LOX and FLAP regulation in human OA chondrocytes by HNE, examined the relative involvement of these two proteins in LTB4 production, and studied the factors that might be responsible for enhanced LTB4 production in these cells incubated for long periods.
Spec (examined) Regulation (regulation) of 5-LOX in chondrocytes associated with osteoarthritis
12) Confidence 0.19 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.19 Pain Relevance 0.13
The effects of aspirin, indomethacin, and ibuprofen on the PMN 15-lipoxygenase were compared in six donors.
Regulation (effects) of lipoxygenase associated with aspirin
13) Confidence 0.18 Published 1984 Journal J. Biol. Chem. Section Abstract Doc Link 6427221 Disease Relevance 0.25 Pain Relevance 0.22
In human platelets, the nonsteroidal anti-inflammatory drug ibuprofen inhibited production of the cyclooxygenase product thromboxane B2 (I50 = 65 microM), whereas the lipoxygenase product 12-HETE was not appreciably affected even at 5 mM ibuprofen.
Neg (not) Regulation (affected) of lipoxygenase in platelets associated with inflammation and cinod
14) Confidence 0.18 Published 1984 Journal J. Biol. Chem. Section Abstract Doc Link 6427221 Disease Relevance 0.36 Pain Relevance 0.18
Several investigations have shown that 5-LOX and FLAP expression is regulated by PGE2 [28,42].
Regulation (regulated) of 5-LOX
15) Confidence 0.16 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.08 Pain Relevance 0.04
Increased 5-lipoxygenase (5-LO) activity reflected in production in the gastric efferent circulation of leukotriene C-4 is shown in pigs given i.g. indomethacin.
Regulation (reflected) of 5-LO
16) Confidence 0.15 Published 1993 Journal Agents Actions Suppl. Section Abstract Doc Link 8372736 Disease Relevance 0.29 Pain Relevance 0.23
These data confirm that LTB4 production is dependent on the regulation of both 5-LOX and FLAP.
Regulation (regulation) of 5-LOX
17) Confidence 0.14 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.06 Pain Relevance 0.03
5-LOX and FLAP are essential proteins responsible for LTB4 synthesis.
Regulation (responsible) of 5-LOX
18) Confidence 0.14 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.36 Pain Relevance 0.18
In our study, we also demonstrated that lower PGE2 production favors the 5-LOX pathway and LTB4 synthesis in HNE-treated OA chondrocytes.
Regulation (favors) of 5-LOX in chondrocytes associated with osteoarthritis
19) Confidence 0.14 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 1.00 Pain Relevance 0.79
The efficacy of the dual-functional COX-2 and 5-LOX inhibitor and the mixture with different concentrations and DR/MR values was investigated and compared.
Spec (investigated) Regulation (efficacy) of 5-LOX
20) Confidence 0.09 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1829479 Disease Relevance 0.20 Pain Relevance 0.16

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