INT281645

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Context Info
Confidence 0.08
First Reported 2009
Last Reported 2009
Negated 3
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.51
Pain Relevance 2.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Phax) RNA binding (Phax) nucleus (Phax)
cytoplasm (Phax)
Anatomy Link Frequency
Paw 2
dorsal horn 2
microglia 2
Phax (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hyperalgesia 6 100.00 Very High Very High Very High
allodynia 15 99.36 Very High Very High Very High
intrathecal 55 99.08 Very High Very High Very High
withdrawal 18 98.94 Very High Very High Very High
Pain 34 97.24 Very High Very High Very High
Dorsal horn 33 96.28 Very High Very High Very High
qutenza 71 88.00 High High
depression 12 86.92 High High
c fibre 19 86.84 High High
analgesia 15 86.36 High High
Disease Link Frequency Relevance Heat
Hyperalgesia 10 100.00 Very High Very High Very High
Neuropathic Pain 39 99.36 Very High Very High Very High
Nervous System Injury 95 98.72 Very High Very High Very High
Pain 32 97.24 Very High Very High Very High
Depression 8 86.92 High High
Nociception 36 84.28 Quite High
Ganglion Cysts 55 81.40 Quite High
Hypersensitivity 24 76.24 Quite High
INFLAMMATION 35 75.24 Quite High
Injury 12 42.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The specificity of intrathecal RTX action was shown by the observation that RTX administration did not affect mechanosensitivity and that staining for TRPV4, a putative mechanosensor, was intact in the dorsal horn.
Neg (not) Regulation (affect) of Gene_expression (administration) of RTX in dorsal horn associated with dorsal horn and intrathecal
1) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737142 Disease Relevance 0.56 Pain Relevance 0.45
Paw withdrawal latency (PWL) to radiant heat was not significantly affected following administration of RTX (control, 7.2±0.6 s, n?
Neg (not) Regulation (affected) of Gene_expression (administration) of RTX in Paw associated with withdrawal
2) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737142 Disease Relevance 0.57 Pain Relevance 0.87
Our data also suggest that p38 activation in spinal microglia is associated with the development of mechanical allodynia but not heat hyperalgesia, because RTX blocks heat hyperalgesia but has no effect on microglial p38 activation and mechanical allodynia after SNI.
Neg (no) Regulation (effect) of Gene_expression (activation) of RTX in microglia associated with hyperalgesia, nervous system injury and allodynia
3) Confidence 0.04 Published 2009 Journal Mol Pain Section Body Doc Link PMC2759920 Disease Relevance 1.37 Pain Relevance 1.12

General Comments

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