INT28165

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Context Info
Confidence 0.47
First Reported 1984
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 38
Total Number 39
Disease Relevance 10.80
Pain Relevance 5.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ALOX5) nuclear envelope (ALOX5) small molecule metabolic process (ALOX5)
oxidoreductase activity (ALOX5) nucleus (ALOX5) cytoplasm (ALOX5)
Anatomy Link Frequency
teeth 3
chondrocytes 2
endothelial cells 1
upper 1
polymorphonuclear leukocytes 1
ALOX5 (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 1 100.00 Very High Very High Very High
Inflammation 265 99.36 Very High Very High Very High
Osteoarthritis 547 98.96 Very High Very High Very High
Enkephalin 7 98.92 Very High Very High Very High
Antinociceptive 19 98.00 Very High Very High Very High
cINOD 53 97.28 Very High Very High Very High
aspirin 8 93.68 High High
licofelone 30 93.24 High High
COX-2 inhibitor 31 92.64 High High
local anesthetic 11 86.56 High High
Disease Link Frequency Relevance Heat
Death 267 100.00 Very High Very High Very High
Pancreatic Cancer 68 99.96 Very High Very High Very High
Injury 26 99.92 Very High Very High Very High
INFLAMMATION 320 99.36 Very High Very High Very High
Osteoarthritis 587 98.96 Very High Very High Very High
Cancer 115 98.80 Very High Very High Very High
Atherosclerosis 86 98.12 Very High Very High Very High
Breast Cancer 37 96.96 Very High Very High Very High
Colon Cancer 15 94.76 High High
Disease 107 94.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of a 15-lipoxygenase/leukotriene pathway in human polymorphonuclear leukocytes by the anti-inflammatory agent ibuprofen.
Positive_regulation (Activation) of lipoxygenase in polymorphonuclear leukocytes associated with inflammation
1) Confidence 0.47 Published 1984 Journal J. Biol. Chem. Section Title Doc Link 6427221 Disease Relevance 0.34 Pain Relevance 0.17
Minocycline has been reported to block 5-lipoxygenase activation [50].
Positive_regulation (activation) of 5-lipoxygenase
2) Confidence 0.45 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3009629 Disease Relevance 0.52 Pain Relevance 0.96
Human aortic endothelial cells cultured in chronically high glucose levels results in elevated levels of 12S-HETE, suggesting activation of lipoxygenase pathways [12, 13].
Positive_regulation (activation) of lipoxygenase in endothelial cells
3) Confidence 0.44 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2878676 Disease Relevance 1.03 Pain Relevance 0.13
But in addition to that, the results showed a statistically highly significant gradual trend between increasing parental LoC and increasing chance of the children to be free from untreated caries and to have intact teeth after adjusting for the effect of for age and sex of the child, parental age and marital status and education of the mother.
Positive_regulation (increasing) of LoC in teeth
4) Confidence 0.42 Published 2008 Journal BMC Public Health Section Body Doc Link PMC2442069 Disease Relevance 0.13 Pain Relevance 0.06
Despite these differences in design and genetic evaluation, both studies observed that polymorphisms in ALOX5 were associated with variation in measures of atherosclerosis (IMT in both studies; CorCP and AorCP in DHS).
Positive_regulation (polymorphisms) of ALOX5 associated with atherosclerosis
5) Confidence 0.41 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2878676 Disease Relevance 0.75 Pain Relevance 0.04
The unexpected observation was made that the human PMN 15-lipoxygenase/leukotriene pathway was selectively activated by 1-5 mM ibuprofen.
Positive_regulation (activated) of lipoxygenase
6) Confidence 0.34 Published 1984 Journal J. Biol. Chem. Section Abstract Doc Link 6427221 Disease Relevance 0.32 Pain Relevance 0.19
Activation of the 15-lipoxygenase by ibuprofen occurred within 1 min and was readily reversible.
Positive_regulation (Activation) of lipoxygenase
7) Confidence 0.31 Published 1984 Journal J. Biol. Chem. Section Abstract Doc Link 6427221 Disease Relevance 0.26 Pain Relevance 0.22
With respect to the children's caries experience (dmft), a similar pattern was observed: increasing trend of ORs referring to the chance of the child to have intact teeth with increasing strength of parental LoC up to the fourth quintile with a slight decrease of OR in the 5th quintile.
Positive_regulation (increasing) of LoC in teeth
8) Confidence 0.30 Published 2008 Journal BMC Public Health Section Body Doc Link PMC2442069 Disease Relevance 0.06 Pain Relevance 0
When dmft was the dependent variable, it was observed that with increasing parental LoC a chance for their children to have intact teeth increased.
Positive_regulation (increasing) of LoC in teeth
9) Confidence 0.30 Published 2008 Journal BMC Public Health Section Body Doc Link PMC2442069 Disease Relevance 0 Pain Relevance 0
There was a statistically highly significant linear trend between increased parental LoC and higher probability of the children to be free from untreated caries, independent from the effect of sociodemographic variables of children and parents.
Positive_regulation (increased) of LoC
10) Confidence 0.28 Published 2008 Journal BMC Public Health Section Abstract Doc Link PMC2442069 Disease Relevance 0.06 Pain Relevance 0
There was a statistically highly significant linear trend between increased parental LoC and higher probability of the children to be free from untreated caries, independent from the effect of sociodemographic variables of children and parents.
Positive_regulation (increased) of LoC
11) Confidence 0.28 Published 2008 Journal BMC Public Health Section Body Doc Link PMC2442069 Disease Relevance 0 Pain Relevance 0
HNE-induced LTB4 release through 5-LOX and FLAP upregulation
Positive_regulation (upregulation) of 5-LOX
12) Confidence 0.25 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.20 Pain Relevance 0.10
Increased 5-lipoxygenase (5-LO) activity reflected in production in the gastric efferent circulation of leukotriene C-4 is shown in pigs given i.g. indomethacin.
Positive_regulation (Increased) of 5-LO
13) Confidence 0.22 Published 1993 Journal Agents Actions Suppl. Section Abstract Doc Link 8372736 Disease Relevance 0.29 Pain Relevance 0.23
An important finding of this study is the inverse relationship between ICP and HD, the inverse relationship between ICP and EHR, the increase of LoS with ICP, the positive relationship between the distance to a specialized cardiology center and EHR as well as LoS, and the negative relationship between the distance to a specialized cardiology center and ICP.
Positive_regulation (increase) of LoS associated with death
14) Confidence 0.22 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1181243 Disease Relevance 0.16 Pain Relevance 0
The paradoxical finding of decreased LoS with proximity to specialized cardiology center while we find an increased LoS with ICP and an increased likelihood of ICP with proximity can be explained by the interaction between ICP and proximity to cardiology center in the evaluation of LoS.
Positive_regulation (increased) of LoS
15) Confidence 0.22 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1181243 Disease Relevance 0.08 Pain Relevance 0
Multiple regression analyses (Table 2) show that the presence of an ICP is correlated with an increased LoS, but with a decreased HD and EHR rates.
Positive_regulation (increased) of LoS associated with death
16) Confidence 0.22 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1181243 Disease Relevance 0.40 Pain Relevance 0
Incubation of cells with naproxen, however, caused a consistent increase of 5-LOX mRNA level by 330% and 570% of control values (P < 0.001) after 24 and 72 hours of incubation, respectively (Figure 6c, d).
Positive_regulation (increase) of 5-LOX
17) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.07 Pain Relevance 0.03
Activation of the lipoxygenase pathway in the methionine enkephalin induced respiratory burst in human polymorphonuclear leukocytes.
Positive_regulation (Activation) of lipoxygenase in respiratory associated with narcan and enkephalin
18) Confidence 0.20 Published 1988 Journal Life Sci. Section Title Doc Link 2836681 Disease Relevance 0 Pain Relevance 0.63
1 induces only 5-LOX mRNA accumulation and not true upregulation of gene expression per se.
Positive_regulation (induces) of 5-LOX
19) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.06 Pain Relevance 0.03
We also observed gender variations in ICP rates, HD rates and LoS.
Positive_regulation (variations) of LoS associated with death
20) Confidence 0.16 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1181243 Disease Relevance 0.26 Pain Relevance 0

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