INT28166

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.40
First Reported 1981
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 25
Disease Relevance 7.96
Pain Relevance 3.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Rem1) GTPase activity (Rem1) cellular_component (Rem1)
biological_process (Rem1)
Anatomy Link Frequency
neurons 8
muscle 1
Rem1 (Mus musculus)
Pain Link Frequency Relevance Heat
fluoxetine 4 99.36 Very High Very High Very High
gABA 288 98.34 Very High Very High Very High
depression 31 97.56 Very High Very High Very High
antidepressant 15 97.36 Very High Very High Very High
Serotonin 12 97.32 Very High Very High Very High
Locus ceruleus 180 97.04 Very High Very High Very High
Dopamine 18 92.32 High High
Neuropeptide 36 90.88 High High
withdrawal 1 89.36 High High
Lasting pain 1 82.64 Quite High
Disease Link Frequency Relevance Heat
Sleep Disorders 847 99.96 Very High Very High Very High
Suicidal Behaviour 83 99.84 Very High Very High Very High
Targeted Disruption 270 99.58 Very High Very High Very High
Sprains And Strains 274 99.42 Very High Very High Very High
Depression 43 97.56 Very High Very High Very High
Psychosis 1 95.12 Very High Very High Very High
Disease 18 84.72 Quite High
Pain 1 82.64 Quite High
Generalized Anxiety Disorder 36 57.56 Quite High
Post-traumatic Stress Disorder 1 31.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
During the 19-24 hours after MS injections, increases of NREM and REM also resulted statistically significant compared to placebo values.
Positive_regulation (increases) of REM
1) Confidence 0.40 Published 1989 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 2727014 Disease Relevance 0.16 Pain Relevance 0.48
These findings suggest that the enhanced REM activity in Wistar-Kyoto rats is less sensitive to the effect of antidepressants and therefore does not provide any additional predictive validity for assessing antidepressant efficacy.
Positive_regulation (enhanced) of REM associated with antidepressant
2) Confidence 0.40 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16223479 Disease Relevance 0.13 Pain Relevance 0.33
Compared to other rat strains, the Wistar-Kyoto rats show increased amount of REM sleep, one of the characteristic sleep changes observed in depressed patients.
Positive_regulation (increased) of REM associated with sprains and strains
3) Confidence 0.40 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16223479 Disease Relevance 0.18 Pain Relevance 0.17
Patients with a history of suicidal behavior showed more REM activity, and REM sleep parameters were not correlated with depression scores.
Positive_regulation (more) of REM associated with suicidal behaviour and depression
4) Confidence 0.37 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656315 Disease Relevance 1.44 Pain Relevance 0.40
Neurons in this area also inhibit REM sleep because when we lesioned it using HCRT2-SAP there was a significant increase in REM sleep [12].
Positive_regulation (increase) of REM in Neurons
5) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.09 Pain Relevance 0.22
Over the 24 h period REM sleep was increased by 20.34% compared to HCRT-ko mice given saline.
Positive_regulation (increased) of REM
6) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0 Pain Relevance 0
These mice have cataplexy, increased REM sleep at night, and more fragmented sleep architecture compared to WT mice [17].
Positive_regulation (increased) of REM associated with sleep disorders
7) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.39 Pain Relevance 0
When these neurons are destroyed, either genetically [3]–[5] or through a chemical neurotoxin [6], REM sleep is enhanced.
Positive_regulation (enhanced) of REM in neurons
8) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.43 Pain Relevance 0.05
An important finding of this study was that lesions of the vlPAG area increased REM sleep but not cataplexy.
Positive_regulation (increased) of REM associated with sleep disorders
9) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.30 Pain Relevance 0.16
We suggest that these neurons may be key to REM sleep generation, but not cataplexy and their activity may underlie the increased REM sleep in the present study.
Positive_regulation (increased) of REM in neurons associated with sleep disorders
10) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.52 Pain Relevance 0.13
Thus, vlPAG lesions in HCRT-ko mice exacerbated the increase in REM sleep but not the wake or non-REM sleep changes.
Positive_regulation (increase) of REM
11) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0 Pain Relevance 0
The second step was to determine the effects of lesion of the vlPAG in the FVB strain of mice. vlPAG lesion in the FVB-GFP transgenic mice produced a 79% increase in REM sleep at night, and a 43% increase over the 24 h period compared to non-lesioned transgenic mice.
Positive_regulation (increase) of REM associated with targeted disruption and sprains and strains
12) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.73 Pain Relevance 0.16
We reasoned that if the vlPAG neurons are important regulators of REM sleep and muscle tone then deletion of both the ligand and the target neurons in the vlPAG should have an additive effect on REM sleep and cataplexy. vlPAG lesion in the HCRT-ko mice increased REM sleep (+39% compared to HCRT-ko; +177% compared to WT), number of bouts of REM sleep, and further fragmented sleep architecture.
Positive_regulation (increased) of REM in muscle associated with sleep disorders
13) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.45 Pain Relevance 0
In cats, electrolytic lesions of the vlPAG [14] or microinjection of muscimol into the vlPAG [15] produces a long lasting increase in REM sleep.
Positive_regulation (increase) of REM
14) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.48 Pain Relevance 0.04
Therefore, the present study tests the hypothesis that vlPAG neurons are inhibitory to REM sleep by destroying these neurons and determining whether there is an increase in REM sleep.
Positive_regulation (increase) of REM in neurons
15) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.25 Pain Relevance 0.03
In humans, loss of HCRT neurons is associated with the sleep disorder narcolepsy and inappropriate triggering of REM sleep [1], [2].
Positive_regulation (triggering) of REM in neurons associated with sleep disorders
16) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.46 Pain Relevance 0.07
Lesions of HCRT receptor bearing neurons in this area in rats does increase REM sleep (56%) [12].
Positive_regulation (increase) of REM in neurons
17) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.42 Pain Relevance 0.08
However, specific lesions of both these targets, either single lesion or in combination (triple), do not increase REM sleep [37].
Positive_regulation (increase) of REM
18) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.22 Pain Relevance 0.26
Subsequently, other investigators found that non-specific lesions of this region with ibotenic acid also increase REM sleep in rats [16].
Positive_regulation (increase) of REM
19) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.08 Pain Relevance 0.18
In rats, ibotenic acid induced nonspecific lesions of the vlPAG increases REM sleep [16].
Positive_regulation (increases) of REM
20) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.49 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox