INT2817

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Context Info
Confidence 0.80
First Reported 1979
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 4.13
Pain Relevance 2.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ltf) extracellular region (Ltf) molecular_function (Ltf)
cellular_component (Ltf) biological_process (Ltf) cytoplasm (Ltf)
Anatomy Link Frequency
plasma 1
dermis 1
external 1
gut 1
duct 1
Ltf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 22 100.00 Very High Very High Very High
Inflammation 10 97.00 Very High Very High Very High
lidocaine 1 94.16 High High
adenocard 1 91.72 High High
spastic colon 1 88.88 High High
Pain 1 69.04 Quite High
Inflammatory response 1 50.00 Quite Low
Codeine 2 10.00 Low Low
Antihistamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatitis 36 100.00 Very High Very High Very High
Autoimmune Disease 6 99.22 Very High Very High Very High
Disease 1 99.00 Very High Very High Very High
INFLAMMATION 4 97.36 Very High Very High Very High
Functional Bowel Disorder 1 88.88 High High
Inflammatory Bowel Disease 4 87.24 High High
Adhesions 1 86.64 High High
Gastrointestinal Disease 2 82.56 Quite High
Diarrhoea 1 70.08 Quite High
Pain 1 69.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The determination of lactoferrin levels in pure pancreatic secretion is an important parameter in the diagnosis of chronic pancreatitis.
Localization (secretion) of lactoferrin associated with chronic pancreatitis
1) Confidence 0.80 Published 1979 Journal Z Gastroenterol Section Abstract Doc Link 532248 Disease Relevance 0.27 Pain Relevance 0.27
Lactoferrin, a major whey protein, is a red iron-binding protein present mainly in external secretions such as breast milk and in polymorphonuclear neutrophils.
Localization (secretions) of Lactoferrin in external
2) Confidence 0.73 Published 2009 Journal Intern. Med. Section Abstract Doc Link 19652425 Disease Relevance 0.58 Pain Relevance 0.15
Lactoferrin secretion is increased in pancreatic secretions in calcified and non-calcified chronic pancreatitis.
Localization (secretion) of Lactoferrin associated with chronic pancreatitis
3) Confidence 0.73 Published 2009 Journal JOP Section Abstract Doc Link 19454813 Disease Relevance 0.64 Pain Relevance 0.27
The coincidental appearance of autoimmune pancreatitis with extrapancreatic autoimmune diseases strongly suggests a common autoimmune mechanism and lactoferrin is a candidate antigen.
Localization (mechanism) of lactoferrin associated with autoimmune disease and pancreatitis
4) Confidence 0.68 Published 2009 Journal JOP Section Abstract Doc Link 19454813 Disease Relevance 0.87 Pain Relevance 0.32
The present review is focused on the clinical significance of lactoferrin in pancreatic secretions and stone formation in chronic pancreatitis, and of serum anti-lactoferrin antibody in autoimmune pancreatitis.
Localization (secretions) of lactoferrin associated with pancreatitis and chronic pancreatitis
5) Confidence 0.68 Published 2009 Journal JOP Section Abstract Doc Link 19454813 Disease Relevance 0.58 Pain Relevance 0.26
Duodenal output and concentration of lactoferrin in chronic pancreatitis: correlation to amylase secretion and duct morphology.
Localization (secretion) of lactoferrin in duct associated with chronic pancreatitis
6) Confidence 0.63 Published 1986 Journal Scand. J. Gastroenterol. Suppl. Section Title Doc Link 2436285 Disease Relevance 0.37 Pain Relevance 0.36
Calprotectin, lactoferrin and nitric oxide are produced and released locally in much greater quantities in the inflamed gut than in the noninflamed gut.
Localization (released) of lactoferrin in gut
7) Confidence 0.56 Published 2005 Journal Nature clinical practice. Gastroenterology & hepatology Section Abstract Doc Link 16265127 Disease Relevance 0.54 Pain Relevance 0.30
The neutrophil count decreases to a lesser extent, but neutrophils also are stimulated to secrete lactoferrin and elastase concomitant with activation of plasma kallikrein.
Localization (secrete) of lactoferrin in plasma
8) Confidence 0.36 Published 1990 Journal Ann. Thorac. Surg. Section Abstract Doc Link 2404474 Disease Relevance 0.09 Pain Relevance 0.14
Many of these neutrophils and eosinophils were activated, releasing more lactoferrin and ECP into the extracellular dermis for at least 24 hours after antigen challenge.
Localization (releasing) of lactoferrin in dermis
9) Confidence 0.32 Published 1997 Journal J. Allergy Clin. Immunol. Section Body Doc Link 9314346 Disease Relevance 0 Pain Relevance 0
Salivary secretion in chronic pancreatitis with special reference to albumin and lactoferrin.
Localization (secretion) of lactoferrin associated with chronic pancreatitis
10) Confidence 0.16 Published 1982 Journal Digestion Section Title Doc Link 7128960 Disease Relevance 0.19 Pain Relevance 0.25

General Comments

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