INT28181

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Context Info
Confidence 0.07
First Reported 1989
Last Reported 2007
Negated 2
Speculated 1
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 0.82
Pain Relevance 8.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 3
tube 1
CSF 1
H2-M3 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 97 99.72 Very High Very High Very High
Eae 10 97.32 Very High Very High Very High
Antinociceptive 1 94.68 High High
Opioid 1 91.32 High High
Pain 11 91.20 High High
visual analogue scale 2 88.96 High High
Bioavailability 1 88.00 High High
epidural 3 75.00 Quite High
Cancer pain 1 75.00 Quite High
analgesia 4 74.80 Quite High
Disease Link Frequency Relevance Heat
Depression 1 95.76 Very High Very High Very High
Pain 6 91.20 High High
Cancer 4 75.92 Quite High
Cancer Pain 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We studied the possible influence of M3G on the psychostimulant properties of morphine and M6G measured by locomotor activity.
Spec (possible) Regulation (influence) of M3G associated with eae and morphine
1) Confidence 0.07 Published 2007 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 17343905 Disease Relevance 0.10 Pain Relevance 1.35
The present results demonstrated no locomotor effect of M3G, but a serum concentration effect relationship for morphine and M6G.
Neg (no) Regulation (effect) of M3G associated with morphine
2) Confidence 0.06 Published 2002 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 12213535 Disease Relevance 0 Pain Relevance 1.54
Constant concentrations of morphine, M3G, and M6G in plasma were achieved during the 5- to 6-hr period of infusion with morphine, as were the concentrations of M3G while M3G was infused.
Regulation (concentrations) of M3G in plasma associated with morphine
3) Confidence 0.02 Published 1995 Journal Drug Metab. Dispos. Section Abstract Doc Link 7628298 Disease Relevance 0 Pain Relevance 0.97
Heparin had no effect on M, M6G or M3G, whereas citrate in a glass tube produced consistently lower concentrations of M, M3G and M6G.
Neg (no) Regulation (effect) of M3G in tube
4) Confidence 0.00 Published 1989 Journal Ann. Clin. Biochem. Section Abstract Doc Link 2729862 Disease Relevance 0 Pain Relevance 0.33
Thus, despite their relatively poor ability to penetrate into the CSF, the high serum concentrations of M6G and M3G resulted in substantial concentrations of these metabolites in the CSF.
Regulation (concentrations) of M3G in CSF
5) Confidence 0.00 Published 1994 Journal Pain Section Abstract Doc Link 8008404 Disease Relevance 0.26 Pain Relevance 1.51
The mean M3G and M6G concentrations in CSF were approximately 8 and 10% of those found in plasma, but there was a wide interindividual variation.
Regulation (concentrations) of M3G in plasma
6) Confidence 0.00 Published 1996 Journal Pain Section Abstract Doc Link 9121807 Disease Relevance 0.23 Pain Relevance 1.27
The mean M3G and M6G concentrations in CSF were 40-60% of those found in plasma.
Regulation (concentrations) of M3G in plasma
7) Confidence 0.00 Published 1993 Journal Pain Section Abstract Doc Link 8455965 Disease Relevance 0.24 Pain Relevance 1.40

General Comments

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