INT281823

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Context Info
Confidence 0.15
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 8
Disease Relevance 2.37
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PRB4) molecular_function (PRB4) biological_process (PRB4)
Anatomy Link Frequency
blood 1
HT-1080 1
PRB4 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 14 98.20 Very High Very High Very High
cva 8 96.52 Very High Very High Very High
IPN 7 96.24 Very High Very High Very High
Inflammation 7 94.68 High High
Potency 14 90.72 High High
imagery 7 47.76 Quite Low
addiction 7 29.56 Quite Low
cytokine 7 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibrosarcoma 56 99.28 Very High Very High Very High
Cancer 91 97.68 Very High Very High Very High
Hemorrhage 9 96.52 Very High Very High Very High
Inflammatory Pain 7 96.24 Very High Very High Very High
Thrombosis 8 95.92 Very High Very High Very High
Hypersensitivity 7 95.72 Very High Very High Very High
INFLAMMATION 7 94.68 High High
Disease 8 91.32 High High
Malignant Neoplastic Disease 7 80.60 Quite High
Hypoxia 7 70.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, PO was synthesized from paeonol with an anticipation of improved solubility and increased anti-angiogenic potential based on the similarity of PO to aspirin.
Gene_expression (synthesized) of PO associated with aspirin
1) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925949 Disease Relevance 0.29 Pain Relevance 0.12
The effect of PO on human HT-1080 fibrosarcoma cells (a highly angiogenic cancer cell line) was investigated.
Spec (investigated) Gene_expression (effect) of PO in HT-1080 associated with fibrosarcoma and cancer
2) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925949 Disease Relevance 0.53 Pain Relevance 0.05
We showed that PO (IC50 ?
Gene_expression (showed) of PO
3) Confidence 0.15 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2925949 Disease Relevance 0.33 Pain Relevance 0
This is one likely reason for the unreliable PO2 values measured in arterialized earlobe blood in patients breathing 100% oxygen.[192122]
Gene_expression (values) of PO2 in blood
4) Confidence 0.14 Published 2008 Journal Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine Section Body Doc Link PMC2738313 Disease Relevance 0.20 Pain Relevance 0
Briefly, PO and bFGF (100 ng) were loaded onto a 1/4 piece of thermonox disc (Nunc, Naperville, IL).
Gene_expression (loaded) of PO
5) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925949 Disease Relevance 0 Pain Relevance 0
PO disrupted bFGF-induced angiogenesis in CAM assay
Gene_expression (disrupted) of PO
6) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925949 Disease Relevance 0.12 Pain Relevance 0.03
Paeonol oxime (1-[2-hydroxy-4-methoxy phenyl] ethanone oxime, PO; molecular weight: 213) was synthesized from paeonol (Fig. 1A).
Gene_expression (synthesized) of PO
7) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925949 Disease Relevance 0.39 Pain Relevance 0
We designed and synthesized PO so that it also shares some similarity with acetylsalicylic acid (Fig. 1), a well known anti-inflammatory pain killer but also with anti-angiogenic activity [1], [14], with the goal to achieve better solubility and anti-angiogenic potency than paeonol.
Gene_expression (synthesized) of PO associated with aspirin, ipn and potency
8) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925949 Disease Relevance 0.50 Pain Relevance 0.19

General Comments

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