INT281849

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Context Info
Confidence 0.17
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.43
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RRM2) nucleoplasm (RRM2) small molecule metabolic process (RRM2)
oxidoreductase activity (RRM2) cytoplasm (RRM2)
RRM2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Analgesic 71 97.08 Very High Very High Very High
imagery 150 81.04 Quite High
Pain score 7 78.24 Quite High
Pain 15 75.88 Quite High
cocaine 216 50.00 Quite Low
addiction 42 30.16 Quite Low
alcohol 54 14.96 Low Low
Pain management 1 12.00 Low Low
Potency 9 8.40 Low Low
Opioid 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 8 82.80 Quite High
Pain 24 78.24 Quite High
Cocaine Dependence 30 30.80 Quite Low
Infection 3 24.64 Low Low
Hepatitis B Virus Infection 2 23.00 Low Low
Hepatitis 1 16.52 Low Low
Nicotine Addiction 21 12.24 Low Low
Drug Dependence 36 5.00 Very Low Very Low Very Low
Congenital Anomalies 22 5.00 Very Low Very Low Very Low
Respiratory Syncytial Virus 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
0.328; R2?
R2 Binding (0.328) of
1) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2738941 Disease Relevance 0.35 Pain Relevance 1.00
Bartlett et al. [24] used a similar multicomponent concept but complexed a ribonucleotide reductase (RRM2) siRNA to cationic cyclodextrin, along with PEG and a targeting ligand, transferrin.
RRM2 Binding (complexed) of
2) Confidence 0.15 Published 2010 Journal Silence Section Body Doc Link PMC2908561 Disease Relevance 0.08 Pain Relevance 0
0.0016, R2?
R2 Binding (0.0016) of
3) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905416 Disease Relevance 0 Pain Relevance 0
0.0216, R2?
R2 Binding (0.0216) of
4) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905416 Disease Relevance 0 Pain Relevance 0.04
0.0250, R2?
R2 Binding (0.0250) of
5) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905416 Disease Relevance 0 Pain Relevance 0.04

General Comments

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