INT28187

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Context Info
Confidence 0.31
First Reported 1989
Last Reported 1989
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.35
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RYBP) small molecule metabolic process (CYP2B6) endoplasmic reticulum (CYP2B6)
nucleus (RYBP) intracellular (RYBP) DNA binding (RYBP)
Anatomy Link Frequency
stems 1
CYP2B6 (Homo sapiens)
RYBP (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 17 100.00 Very High Very High Very High
Analgesic 1 92.64 High High
alcohol 1 90.72 High High
Disease Link Frequency Relevance Heat
Hepatotoxicity 2 99.76 Very High Very High Very High
Necrosis 1 95.76 Very High Very High Very High
Toxicity 1 59.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hepatotoxicity stems from APAP activation by microsomal P450 monooxygenases to a reactive metabolite that binds to tissue macromolecules, thereby initiating cellular necrosis.
P450 Positive_regulation (activation) of APAP in stems associated with necrosis, paracetamol and hepatotoxicity
1) Confidence 0.31 Published 1989 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 2729995 Disease Relevance 0.35 Pain Relevance 0.76

General Comments

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