INT281872

Context Info Confidence 0.20 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 1.30 Pain Relevance 0.12

cytosol (Aco1) mitochondrion (Aco1) lyase activity (Aco1) Golgi apparatus (Aco1) endoplasmic reticulum (Aco1) RNA binding (Aco1)

Anatomy Link Frequency neuronal 2 Aco1 (Mus musculus)

Pain Link Frequency Relevance Heat midbrain 54 83.44 addiction 3 55.76 ischemia 3 54.72 Substantia nigra 3 5.00 Inflammation 3 5.00 Pain 3 5.00

Disease Link Frequency Relevance Heat Death 177 99.64 Toxicity 12 91.76 Parkinson's Disease 33 83.92 Stress 36 76.68 Aging 3 60.68 Alzheimer's Dementia 3 55.48 Cv General 4 Under Development 3 54.72 Drug Induced Neurotoxicity 24 50.00 Epilepsy 3 46.16 Ataxia 3 45.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Oxidative inactivation of m-aconitase leads to cell death

Positive_regulation (leads) of Positive_regulation (inactivation) of m-aconitase associated with death

1) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2738973 Disease Relevance 0.40 Pain Relevance 0

Our data demonstrate that oxidative inactivation of m-aconitase results in the formation of Fenton reactants in neuronal cells which provides evidence for the pathogenic mechanism in which m-aconitase not only serves as a target but also as a source of oxidants.

Positive_regulation (results) of Positive_regulation (inactivation) of m-aconitase in neuronal

2) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2738973 Disease Relevance 0.83 Pain Relevance 0.03

Oxidative inactivation of overexpressed m-aconitase exacerbates H2O2 production and mitochondrial iron accumulation

Positive_regulation (exacerbates) of Positive_regulation (inactivation) of m-aconitase

3) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2738973 Disease Relevance 0.07 Pain Relevance 0.10

General Comments

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