INT281872

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Context Info
Confidence 0.20
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.30
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Aco1) mitochondrion (Aco1) lyase activity (Aco1)
Golgi apparatus (Aco1) endoplasmic reticulum (Aco1) RNA binding (Aco1)
Anatomy Link Frequency
neuronal 2
Aco1 (Mus musculus)
Pain Link Frequency Relevance Heat
midbrain 54 83.44 Quite High
addiction 3 55.76 Quite High
ischemia 3 54.72 Quite High
Substantia nigra 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 177 99.64 Very High Very High Very High
Toxicity 12 91.76 High High
Parkinson's Disease 33 83.92 Quite High
Stress 36 76.68 Quite High
Aging 3 60.68 Quite High
Alzheimer's Dementia 3 55.48 Quite High
Cv General 4 Under Development 3 54.72 Quite High
Drug Induced Neurotoxicity 24 50.00 Quite Low
Epilepsy 3 46.16 Quite Low
Ataxia 3 45.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Oxidative inactivation of m-aconitase leads to cell death
Positive_regulation (leads) of Positive_regulation (inactivation) of m-aconitase associated with death
1) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2738973 Disease Relevance 0.40 Pain Relevance 0
Our data demonstrate that oxidative inactivation of m-aconitase results in the formation of Fenton reactants in neuronal cells which provides evidence for the pathogenic mechanism in which m-aconitase not only serves as a target but also as a source of oxidants.
Positive_regulation (results) of Positive_regulation (inactivation) of m-aconitase in neuronal
2) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2738973 Disease Relevance 0.83 Pain Relevance 0.03
Oxidative inactivation of overexpressed m-aconitase exacerbates H2O2 production and mitochondrial iron accumulation
Positive_regulation (exacerbates) of Positive_regulation (inactivation) of m-aconitase
3) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2738973 Disease Relevance 0.07 Pain Relevance 0.10

General Comments

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