INT281876

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.11
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.00
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Aco1) mitochondrion (Aco1) lyase activity (Aco1)
Golgi apparatus (Aco1) endoplasmic reticulum (Aco1) RNA binding (Aco1)
Aco1 (Mus musculus)
Pain Link Frequency Relevance Heat
midbrain 54 88.00 High High
ischemia 3 76.16 Quite High
Inflammation 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
Substantia nigra 3 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
Thoracotomy 1 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 33 99.24 Very High Very High Very High
Stress 37 98.12 Very High Very High Very High
Death 177 94.04 High High
Neurodegenerative Disease 12 90.56 High High
Toxicity 12 90.08 High High
Disease 27 83.20 Quite High
Supranuclear Palsy 3 82.48 Quite High
Aging 3 82.12 Quite High
Ataxia 3 78.88 Quite High
Epilepsy 3 77.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Collectively, these studies demonstrate that m-aconitase is a sensitive target of ROS generated in cells and tissue.
Regulation (target) of m-aconitase
1) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2738973 Disease Relevance 1.36 Pain Relevance 0.04
This suggests that in addition to its well known role as a target of ROS, m-aconitase can also be a source of ROS and iron which are neurotoxic.
Regulation (target) of m-aconitase
2) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2738973 Disease Relevance 1.34 Pain Relevance 0.15
Work in our laboratory in the MPTP mouse model of parkinsonism suggests that in addition to being a target of ROS, m-aconitase may also be an important source of mitochondrial iron [16].
Regulation (target) of m-aconitase associated with parkinson's disease
3) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2738973 Disease Relevance 1.30 Pain Relevance 0.03
To determine if this occurred, we selected three candidate enzymes from the proteins identified as targets of S-nitrosation: mitochondrial aconitase, ?
Regulation (nitrosation) of aconitase
4) Confidence 0.02 Published 2010 Journal Biochemical Journal Section Body Doc Link PMC2911678 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox