INT28188

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.62
First Reported 1989
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 0.48
Pain Relevance 2.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP2E1) oxidoreductase activity (CYP2E1) endoplasmic reticulum (CYP2E1)
enzyme binding (CYP2E1)
Anatomy Link Frequency
liver 3
plasma 1
lymphocytes 1
CYP2E1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 27 98.44 Very High Very High Very High
alcohol 119 89.12 High High
Lamotrigine 8 81.12 Quite High
Gabapentin 5 80.60 Quite High
Antiepileptic agent 1 79.48 Quite High
antiepileptic Drug 20 75.00 Quite High
anticonvulsant 2 72.08 Quite High
carbamazepine 13 69.80 Quite High
Potency 1 63.32 Quite High
Migraine 1 60.56 Quite High
Disease Link Frequency Relevance Heat
Toxicity 16 98.48 Very High Very High Very High
Alcohol Addiction 24 98.24 Very High Very High Very High
Headache 7 60.56 Quite High
Epilepsy 24 50.00 Quite Low
Convulsion 35 48.76 Quite Low
Stress 7 45.16 Quite Low
Necrosis 2 40.32 Quite Low
Hepatotoxicity 2 33.92 Quite Low
Disorder Of Lipid Metabolism 2 30.68 Quite Low
Parkinson's Disease 2 23.92 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Little information, however, is available about the effects of environmental VOCs on CYP2E1 regulation in human peripheral lymphocytes.
Regulation (regulation) of CYP2E1 in lymphocytes
1) Confidence 0.62 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440770 Disease Relevance 0 Pain Relevance 0
The levels of other CYP proteins, including CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP2E1, were not affected by eletriptan.
Neg (not) Regulation (affected) of CYP2E1
2) Confidence 0.54 Published 2000 Journal Drug Metab. Dispos. Section Abstract Doc Link 10611140 Disease Relevance 0.06 Pain Relevance 0.15
Toluene effects on CYP2E1 phenotype.
Regulation (effects) of CYP2E1
3) Confidence 0.45 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440770 Disease Relevance 0 Pain Relevance 0
Two aspects have been particularly taken into account: the changes or absence of changes in plasma/serum concentrations of concomitant drugs and the direct or indirect evidence of induction, inhibition or lack of effect on the six major human hepatic CYP isozymes (CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP2E1 and CYP3A4), as well as on other CYP isozymes or enzyme systems.
Regulation (effect) of CYP2E1 in plasma
4) Confidence 0.37 Published 2000 Journal Fundam Clin Pharmacol Section Abstract Doc Link 11030437 Disease Relevance 0 Pain Relevance 0.20
In addition, ethanol may induce up to a 10-fold up-regulation of CYP2E1 in the liver, which may be responsible for alcoholism-triggered oxidative damage [85–87].
Regulation (regulation) of CYP2E1 in liver associated with alcohol addiction
5) Confidence 0.31 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872347 Disease Relevance 0.10 Pain Relevance 0.23
The CYP2E1 response we observed in this study demonstrated that toluene exposure affects CYP2E1 mRNA content, but more studies on toluene toxicity are needed to fully characterize the mechanism of induction.
Regulation (affects) of CYP2E1 mRNA associated with toxicity
6) Confidence 0.27 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440770 Disease Relevance 0.10 Pain Relevance 0
Other chemicals, such as ethanol, can regulate CYP2E1 activity by altering protein stabilization without affecting transcriptional activity (Roberts et al. 1995).
Regulation (regulate) of CYP2E1
7) Confidence 0.27 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440770 Disease Relevance 0.10 Pain Relevance 0
The mRNA response is the first step after its modulation and may not be affected by other factors that modify CYP2E1 enzyme activity, as has been suggested to be a complicating factor for CHZ metabolism.
Regulation (modify) of CYP2E1
8) Confidence 0.27 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440770 Disease Relevance 0.07 Pain Relevance 0
We conclude that the time course of the interaction with regard to chlorzoxazone elimination and formation is compatible with an inhibition-induction effect of isoniazid on cytochrome P4502E1.
Regulation (effect) of cytochrome P4502E1
9) Confidence 0.27 Published 1993 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 8354023 Disease Relevance 0 Pain Relevance 0.35
The activity of CYP1A2, CYP2A6, CYP2B6, CYP2D6, CYP2E1, CYP3A4, and CYP2C9 was not affected, and only a moderate inhibitory effect on CYP2C19 (by 38%), as well as a moderate increment of UDP-glucuronosyl-transferase 1A1-mediated ethinylestradiol glucuronidation (by 39%), was seen in the presence of ESL in human liver microsomes in vitro.36

In vivo studies

Neg (not) Regulation (affected) of CYP2E1 in liver
10) Confidence 0.09 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2987506 Disease Relevance 0 Pain Relevance 0.17
The ability of anti-P450IIE1 IgG to inhibit only one-half of the total APAP activation by microsomes suggests, however, that other P450 isozymes besides P450IIE1 contribute to bioactivation of this compound in human liver.
Regulation (contribute) of P450IIE1 in liver associated with paracetamol
11) Confidence 0.07 Published 1989 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 2729995 Disease Relevance 0.06 Pain Relevance 0.94

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox