INT28190

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Context Info
Confidence 0.38
First Reported 1989
Last Reported 2009
Negated 1
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 1.46
Pain Relevance 4.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RYBP) nucleus (RYBP) intracellular (RYBP)
DNA binding (RYBP) cytoplasm (RYBP)
Anatomy Link Frequency
liver 4
kidney 2
RYBP (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 52 100.00 Very High Very High Very High
Endocannabinoid 1 99.56 Very High Very High Very High
Analgesic 8 93.04 High High
Pain 4 86.76 High High
alcohol 1 83.32 Quite High
Central nervous system 1 83.16 Quite High
addiction 1 60.36 Quite High
Disease Link Frequency Relevance Heat
Toxicity 6 98.88 Very High Very High Very High
Hepatotoxicity 4 98.48 Very High Very High Very High
Pain 3 86.76 High High
Necrosis 3 82.96 Quite High
Nephrotoxicity 5 81.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, endocannabinoid signaling may play a role in APAP's activation of the serotonergic descending inhibitory pathways.
Regulation (role) of Positive_regulation (activation) of APAP associated with endocannabinoid and paracetamol
1) Confidence 0.38 Published 2009 Journal Pain Physician Section Abstract Doc Link 19165309 Disease Relevance 0.23 Pain Relevance 1.52
We therefore examined the role of P450IIE1 in human liver microsomal APAP activation.
Spec (examined) Regulation (role) of Spec (examined) Positive_regulation (activation) of APAP in liver associated with paracetamol
2) Confidence 0.15 Published 1989 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 2729995 Disease Relevance 0.33 Pain Relevance 1.08
These results indicate that in rat liver there is only slight perivenous zonation of APAP conjugation and suggest that zone-specific APAP activation, mediated by the regional expression of ethanol-inducible cytochrome P450 2E1, is responsible for the characteristic centrilobular liver damage elicited by APAP.
Regulation (responsible) of Positive_regulation (activation) of APAP in liver associated with paracetamol and hepatotoxicity
3) Confidence 0.10 Published 1993 Journal Biochem. Pharmacol. Section Abstract Doc Link 8466546 Disease Relevance 0.31 Pain Relevance 0.87
Testosterone pretreatment, in vivo, also resulted in increased activation of APAP in vitro in kidney microsomes with no effect on the in vitro activation of APAP in liver microsomes.
Neg (no) Regulation (effect) of Positive_regulation (activation) of APAP in kidney associated with paracetamol
4) Confidence 0.05 Published 1995 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 7871539 Disease Relevance 0.59 Pain Relevance 1.00

General Comments

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