INT28191

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Context Info
Confidence 0.49
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.50
Pain Relevance 2.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP2E1) oxidoreductase activity (CYP2E1) endoplasmic reticulum (CYP2E1)
enzyme binding (CYP2E1)
Anatomy Link Frequency
blood 2
liver 2
CYP2E1 (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 63 99.92 Very High Very High Very High
cytokine 21 97.28 Very High Very High Very High
Paracetamol 211 95.96 Very High Very High Very High
Analgesic 13 85.64 High High
Inflammation 54 79.84 Quite High
Bile 3 64.24 Quite High
abdominal pain 6 49.56 Quite Low
Inflammatory response 11 48.08 Quite Low
anesthesia 15 37.44 Quite Low
fibrosis 19 30.92 Quite Low
Disease Link Frequency Relevance Heat
Injury 78 99.08 Very High Very High Very High
Necrosis 13 98.92 Very High Very High Very High
Appetite Loss 8 97.56 Very High Very High Very High
Nicotine Addiction 54 96.12 Very High Very High Very High
Hepatotoxicity 8 92.52 High High
Liver Failure 5 90.92 High High
Death 57 88.08 High High
Liver Disease 45 87.36 High High
Stress 107 82.88 Quite High
Pneumonia 3 79.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It seems to increase blood flow and the elimination of sevoflurane due to the induction of CYP2E1.
Positive_regulation (increase) of Positive_regulation (induction) of CYP2E1 in blood
1) Confidence 0.49 Published 2010 Journal BMC Anesthesiol Section Body Doc Link PMC2905413 Disease Relevance 1.10 Pain Relevance 0.04
Conditions which can increase NAPQI production, such as induction of CYP2E1 by alcohol, or conditions that decrease GSH stores, such as malnutrition, are postulated to increase the risk of acetaminophen-induced hepatic injury [5,17,19-24].
Positive_regulation (increase) of Positive_regulation (induction) of CYP2E1 associated with appetite loss, paracetamol, injury and alcohol
2) Confidence 0.45 Published 2007 Journal BMC Med Section Body Doc Link PMC1894983 Disease Relevance 0.52 Pain Relevance 0.71
This period exhibits the largest increase in CYP2E1 induction and lowest glutathione levels.
Positive_regulation (increase) of Positive_regulation (induction) of CYP2E1
3) Confidence 0.41 Published 2007 Journal BMC Med Section Abstract Doc Link PMC1894983 Disease Relevance 0.09 Pain Relevance 0.41
The actual list includes genes encoding cytochrome P450 isoform CYP2E1, alcohol-dehydrogenases (ADHs), and Mn-SOD, as well as a number of cytokines, including TGF?
Positive_regulation (encoding) of Positive_regulation (cytochrome) of CYP2E1 associated with cytokine and alcohol
4) Confidence 0.26 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 1.44 Pain Relevance 0.19
Alcohol consumption also causes the induction of P450IIE1, a liver microsomal enzyme that in reconstitution studies has proven to be an effective catalyst of APAP oxidation.
Positive_regulation (causes) of Positive_regulation (induction) of P450IIE1 in liver associated with paracetamol and alcohol
5) Confidence 0.11 Published 1989 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 2729995 Disease Relevance 0.35 Pain Relevance 0.91

General Comments

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