INT281919

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Context Info
Confidence 0.75
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.69
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (ACE2) extracellular space (ACE2) extracellular region (ACE2)
plasma membrane (ACE2)
Anatomy Link Frequency
epithelium 1
neutrophils 1
ACE2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 99 99.28 Very High Very High Very High
Osteoarthritis 50 98.24 Very High Very High Very High
corticosteroid 1 87.64 High High
Pain 33 84.44 Quite High
Inflammatory mediators 4 80.32 Quite High
rheumatoid arthritis 1 75.44 Quite High
cytokine 16 70.76 Quite High
anesthesia 1 65.92 Quite High
Pain score 12 45.40 Quite Low
antagonist 5 38.28 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 111 99.28 Very High Very High Very High
Adhesions 6 98.72 Very High Very High Very High
Osteoarthritis 50 98.24 Very High Very High Very High
Dengue Hemorrhagic Fever 205 97.90 Very High Very High Very High
Systemic Lupus Erythematosus 24 93.60 High High
Necrosis 9 92.00 High High
Pressure And Volume Under Development 2 84.96 Quite High
Pain 43 84.44 Quite High
Synovitis 1 80.80 Quite High
Atherosclerosis 3 76.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The signal intensities of ACE2 protein and the IgG heavy chain shown in Figure 3d were measured and normalized.


Localization (normalized) of ACE2 protein
1) Confidence 0.75 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911869 Disease Relevance 0.31 Pain Relevance 0.07
In the rat, Ang-(1–7) and ACE2 localize in the primary and secondary decidual zone, and in the luminal and glandular epithelium.
Localization (localize) of ACE2 in epithelium
2) Confidence 0.54 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.07 Pain Relevance 0
In this study to find out possible mechanism of actions of Aflapin we carried out in vitro studies to evaluate whether Aflapin can inhibit metalloprotease secretion or influence the inflammatory component of osteoarthritis.
Localization (secretion) of metalloprotease associated with inflammation and osteoarthritis
3) Confidence 0.02 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2974165 Disease Relevance 1.15 Pain Relevance 0.74
A putative neutrophil origin of this gene expression pattern is however supported by the over-expression in DSS patients blood cells of transcripts encoding other neutrophil-related molecules such as the MMP8 matrix metalloprotease, CEACAM-6, CEACAM-8 and CD99L2 adhesion molecules (Tables 4 and S2) involved in the recruitment of neutrophils to vascular endothelia.
Localization (metalloprotease) of metalloprotease in neutrophils associated with dengue hemorrhagic fever and adhesions
4) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2907396 Disease Relevance 1.16 Pain Relevance 0.22

General Comments

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