INT281926

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Context Info
Confidence 0.47
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.19
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (ACE2) extracellular space (ACE2) extracellular region (ACE2)
plasma membrane (ACE2)
Anatomy Link Frequency
arterial endothelium 2
ACE2 (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 18 70.32 Quite High
bradykinin 11 39.56 Quite Low
antagonist 5 30.96 Quite Low
fibrosis 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Hypertension 31 99.16 Very High Very High Very High
Pre-eclampsia 33 98.48 Very High Very High Very High
Disease 31 86.08 High High
Cv Unclassified Under Development 18 70.32 Quite High
Skin Ulcer 1 68.00 Quite High
Systemic Lupus Erythematosus 24 47.28 Quite Low
Congenital Anomalies 2 35.76 Quite Low
Systemic Sclerosis 28 28.32 Quite Low
Necrosis 7 9.84 Low Low
Increased Venous Pressure Under Development 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
With the exception of an increased expression of ACE2 in umbilical arterial endothelium in preeclampsia, the expression of Ang-(1–7) and ACE2 is similar in different cell types in reproductive tissues from normal term or preeclamptic pregnancies.
Neg (exception) Positive_regulation (increased) of Gene_expression (expression) of ACE2 in arterial endothelium associated with pre-eclampsia
1) Confidence 0.47 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.30 Pain Relevance 0
Recent studies have demonstrated the therapeutic effects of ACE2 activation by a synthetic molecule [5] or of ACE2 gene transfer [6] in experimental pulmonary hypertension models.
Positive_regulation (transfer) of Gene_expression (transfer) of ACE2 associated with pulmonary hypertension
2) Confidence 0.47 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911869 Disease Relevance 0.89 Pain Relevance 0.04

General Comments

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