INT281928

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Context Info
Confidence 0.77
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 99
Disease Relevance 63.17
Pain Relevance 2.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (ARG2) small molecule metabolic process (ARG2) cellular nitrogen compound metabolic process (ARG2)
Anatomy Link Frequency
22RV1 3
T cells 3
lymphocytes 2
macrophages 1
stroma 1
ARG2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 679 99.58 Very High Very High Very High
Inflammation 99 95.76 Very High Very High Very High
agonist 99 95.40 Very High Very High Very High
palliative 97 76.84 Quite High
bradykinin 22 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
aspirin 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 1 5238 100.00 Very High Very High Very High
Cancer 3589 99.84 Very High Very High Very High
Malignant Neoplastic Disease 970 99.60 Very High Very High Very High
Hyperplasia 388 99.22 Very High Very High Very High
Recurrence 97 99.04 Very High Very High Very High
Toxicity 97 98.60 Very High Very High Very High
Colon Cancer 97 96.80 Very High Very High Very High
Breast Cancer 97 96.04 Very High Very High Very High
Pre-eclampsia 66 95.80 Very High Very High Very High
INFLAMMATION 99 95.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also observed that androgen deprivation in vitro could decrease ARG2, but not ARG1 protein expression, in LNCaP and 22RV1 cells cultured for seven days in the absence of androgens (Figure 3B).
Gene_expression (expression) of ARG2 in 22RV1
1) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.61 Pain Relevance 0
IL-8 induction of ARG1 and ARG2 expression
Gene_expression (expression) of ARG2
2) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.45 Pain Relevance 0.16
We observed that, compared to control cancer patients (surgery only), ADT-treated patients (ADT prior to surgery) had significantly lower ARG2 expression in both the non-malignant tissues adjacent to the tumor (46.4 vs 23.5 relative units; p<0.001, Mann-U) and the tumor tissues (41.7 vs 31.5 relative units; p<0.01, Mann-U) (Figure 3A).
Gene_expression (expression) of ARG2 associated with malignant neoplastic disease and cancer
3) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.64 Pain Relevance 0
As arginases are well-documented to participate in the sculpting of the tumor immunological microenvironment [15] and that cytokines are known to induce arginase expression in murine models [16], we assessed whether cytokines could also regulate arginase expression in human PCa.
Gene_expression (expression) of arginase associated with cancer, reprotox - general 1 and cytokine
4) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.51 Pain Relevance 0.19
Taken together, these results suggest that androgens regulate the expression of ARG2 in vivo in PCa patients as ADT reduces ARG2 expression.


Gene_expression (expression) of ARG2 associated with reprotox - general 1
5) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.56 Pain Relevance 0
It is important to note that expression of ARG1 and ARG2 following IL-8 stimulation was not as substantial as with R1881 stimulation suggesting that other androgen-regulated pathways could be involved.
Gene_expression (expression) of ARG2
6) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.58 Pain Relevance 0.04
We observed that inhibition of either ARG1 or ARG2 expression resulted in a lower proliferation of LNCaP cells maintained in complete media (p?
Gene_expression (expression) of ARG2
7) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.10 Pain Relevance 0
In this report, we observed that androgens induced the expression of both ARG1 and ARG2 in HS PCa cell lines.
Gene_expression (expression) of ARG2 associated with reprotox - general 1
8) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.75 Pain Relevance 0
Taken together, these results suggest that androgens regulate the expression of ARG2 in vivo in PCa patients as ADT reduces ARG2 expression.


Gene_expression (expression) of ARG2 associated with reprotox - general 1
9) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.58 Pain Relevance 0
Diminished ARG2 expression in PCa patients following ADT
Gene_expression (expression) of ARG2 associated with reprotox - general 1
10) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.49 Pain Relevance 0.03
Our hypothesis was that androgens could regulate the expression of ARG2 by PCa cells.


Gene_expression (expression) of ARG2 associated with reprotox - general 1
11) Confidence 0.77 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2920336 Disease Relevance 0.95 Pain Relevance 0
As arginases are well-documented to participate in the sculpting of the tumor immunological microenvironment [15] and that cytokines are known to induce arginase expression in murine models [16], we assessed whether cytokines could also regulate arginase expression in human PCa.
Gene_expression (expression) of arginase associated with cancer, reprotox - general 1 and cytokine
12) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.51 Pain Relevance 0.18
Our data demonstrate that PCa cell lines express both ARG1 and ARG2.
Gene_expression (express) of ARG2 associated with reprotox - general 1
13) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 1.02 Pain Relevance 0
ARG2 was predominantly expressed by HS PCa cell lines and by non-malignant prostate tissues.
Gene_expression (expressed) of ARG2 associated with malignant neoplastic disease and reprotox - general 1
14) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 1.35 Pain Relevance 0
Finally, we showed that IL-8 was also regulated by R1881 and could stimulate the expression of ARG1 and ARG2 independently of androgen.
Gene_expression (expression) of ARG2
15) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 1.20 Pain Relevance 0
We then evaluated whether inhibition of IL-8 could diminish ARG1 and ARG2 expression following R1881 stimulation.
Gene_expression (expression) of ARG2
16) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.32 Pain Relevance 0.14
Furthermore, in order to study whether ARG1 and ARG2 expression by LNCaP cells affected their immunosuppressive potential, PBMCs from healthy donors were activated in the presence of conditioned media from LNCaP+siCTRL or LNCaP+siARG1 or LNCaP+siARG2.
Gene_expression (expression) of ARG2
17) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.09 Pain Relevance 0
Contrary to ARG2 gene and protein expression, we clearly demonstrated that the gene and protein expression of ARG1 did not correlate.
Gene_expression (expression) of ARG2
18) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.92 Pain Relevance 0
In fact, since the prostate is the organ with the highest polyamine production, arginase expression by prostate cells may precede the development of cancer, as polyamine production is essential for the proliferation of prostate cells.
Gene_expression (expression) of arginase associated with cancer
19) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.91 Pain Relevance 0
ARG2 protein abundance correlated with the qPCR results with LNCaP cells expressing significantly more ARG2 than the other three cell lines (Figure 1B, bottom panel).
Gene_expression (expressing) of ARG2
20) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.70 Pain Relevance 0

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