INT281973

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Context Info
Confidence 0.30
First Reported 2009
Last Reported 2009
Negated 0
Speculated 4
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 2.52
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (MDK) signal transduction (MDK) extracellular region (MDK)
Anatomy Link Frequency
lung 6
fibroblasts 2
MDK (Homo sapiens)
Pain Link Frequency Relevance Heat
corticosteroid 48 99.84 Very High Very High Very High
dexamethasone 288 96.84 Very High Very High Very High
Inflammation 12 65.56 Quite High
ketamine 6 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 276 99.88 Very High Very High Very High
Targeted Disruption 18 90.12 High High
Hypoxia 6 84.44 Quite High
INFLAMMATION 6 65.56 Quite High
Cancer 6 64.52 Quite High
Bronchopulmonary Dysplasia 54 49.76 Quite Low
Pneumonia 6 37.44 Quite Low
Infection 6 12.32 Low Low
Hyperglycemia 6 11.44 Low Low
Emphysema 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We therefore examined the effect of different hormone combinations on MK expression.
Spec (examined) Regulation (effect) of Gene_expression (expression) of MK
1) Confidence 0.30 Published 2009 Journal Respir Res Section Body Doc Link PMC2739515 Disease Relevance 0.33 Pain Relevance 0.26
Changes in Tie1 expression during hormonal treatment partially correlated with the changes in MK expression and lung morphology
Regulation (changes) of Gene_expression (expression) of MK in lung
2) Confidence 0.26 Published 2009 Journal Respir Res Section Body Doc Link PMC2739515 Disease Relevance 0.36 Pain Relevance 0.20
LWG was responsible for the determination of MK expression in alveolar type II cells and fibroblasts.
Spec (determination) Regulation (responsible) of Gene_expression (expression) of MK in fibroblasts
3) Confidence 0.13 Published 2009 Journal Respir Res Section Body Doc Link PMC2739515 Disease Relevance 0.05 Pain Relevance 0.06
We conclude that MK is expressed by AT2 cells, and is differentially regulated by corticosteroid and retinoid treatment in a manner consistent with hormonal effects on alveolarization during postnatal lung development.



Regulation (regulated) of Gene_expression (expressed) of MK in lung associated with corticosteroid
4) Confidence 0.13 Published 2009 Journal Respir Res Section Abstract Doc Link PMC2739515 Disease Relevance 0.62 Pain Relevance 0.48
While these observations provided a potential mechanism for the integration of GC and retinoid effects in late gestation fetal lung development, whether GC and RA also influence MK gene expression during postnatal lung development remained unknown.
Spec (whether) Regulation (influence) of Gene_expression (expression) of MK gene in lung associated with rheumatoid arthritis
5) Confidence 0.13 Published 2009 Journal Respir Res Section Body Doc Link PMC2739515 Disease Relevance 0.50 Pain Relevance 0
The purpose of this study was to examine regulation of MK expression by GC and RA during postnatal alveolar formation in neonatal rat pups.
Spec (examine) Regulation (regulation) of Spec (examine) Gene_expression (expression) of MK associated with rheumatoid arthritis
6) Confidence 0.13 Published 2009 Journal Respir Res Section Body Doc Link PMC2739515 Disease Relevance 0.65 Pain Relevance 0.10

General Comments

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