INT281973

Context Info Confidence 0.30 First Reported 2009 Last Reported 2009 Negated 0 Speculated 4 Reported most in Body Documents 1 Total Number 6 Disease Relevance 2.52 Pain Relevance 1.11

cell differentiation (MDK) signal transduction (MDK) extracellular region (MDK)

Anatomy Link Frequency lung 6 fibroblasts 2 MDK (Homo sapiens)

Pain Link Frequency Relevance Heat corticosteroid 48 99.84 dexamethasone 288 96.84 Inflammation 12 65.56 ketamine 6 5.00 anesthesia 6 5.00 alcohol 6 5.00

Disease Link Frequency Relevance Heat Rheumatoid Arthritis 276 99.88 Targeted Disruption 18 90.12 Hypoxia 6 84.44 INFLAMMATION 6 65.56 Cancer 6 64.52 Bronchopulmonary Dysplasia 54 49.76 Pneumonia 6 37.44 Infection 6 12.32 Hyperglycemia 6 11.44 Emphysema 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We therefore examined the effect of different hormone combinations on MK expression.

Spec (examined) Regulation (effect) of Gene_expression (expression) of MK

1) Confidence 0.30 Published 2009 Journal Respir Res Section Body Doc Link PMC2739515 Disease Relevance 0.33 Pain Relevance 0.26

Changes in Tie1 expression during hormonal treatment partially correlated with the changes in MK expression and lung morphology

Regulation (changes) of Gene_expression (expression) of MK in lung

2) Confidence 0.26 Published 2009 Journal Respir Res Section Body Doc Link PMC2739515 Disease Relevance 0.36 Pain Relevance 0.20

LWG was responsible for the determination of MK expression in alveolar type II cells and fibroblasts.

Spec (determination) Regulation (responsible) of Gene_expression (expression) of MK in fibroblasts

3) Confidence 0.13 Published 2009 Journal Respir Res Section Body Doc Link PMC2739515 Disease Relevance 0.05 Pain Relevance 0.06

We conclude that MK is expressed by AT2 cells, and is differentially regulated by corticosteroid and retinoid treatment in a manner consistent with hormonal effects on alveolarization during postnatal lung development.

Regulation (regulated) of Gene_expression (expressed) of MK in lung associated with corticosteroid

4) Confidence 0.13 Published 2009 Journal Respir Res Section Abstract Doc Link PMC2739515 Disease Relevance 0.62 Pain Relevance 0.48

While these observations provided a potential mechanism for the integration of GC and retinoid effects in late gestation fetal lung development, whether GC and RA also influence MK gene expression during postnatal lung development remained unknown.

Spec (whether) Regulation (influence) of Gene_expression (expression) of MK gene in lung associated with rheumatoid arthritis

5) Confidence 0.13 Published 2009 Journal Respir Res Section Body Doc Link PMC2739515 Disease Relevance 0.50 Pain Relevance 0

The purpose of this study was to examine regulation of MK expression by GC and RA during postnatal alveolar formation in neonatal rat pups.

Spec (examine) Regulation (regulation) of Spec (examine) Gene_expression (expression) of MK associated with rheumatoid arthritis

6) Confidence 0.13 Published 2009 Journal Respir Res Section Body Doc Link PMC2739515 Disease Relevance 0.65 Pain Relevance 0.10

General Comments

This test has worked.