INT281977

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Context Info
Confidence 0.29
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 3.05
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (MDK) signal transduction (MDK) extracellular region (MDK)
Anatomy Link Frequency
lung 6
epithelial cells 2
fibroblasts 2
MDK (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 288 100.00 Very High Very High Very High
corticosteroid 48 99.84 Very High Very High Very High
Inflammation 12 92.08 High High
ketamine 6 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 276 99.78 Very High Very High Very High
Bronchopulmonary Dysplasia 54 98.64 Very High Very High Very High
INFLAMMATION 6 92.08 High High
Cancer 6 91.04 High High
Targeted Disruption 18 85.32 High High
Hypoxia 6 78.84 Quite High
Pneumonia 6 49.28 Quite Low
Infection 6 24.16 Low Low
Hyperglycemia 6 23.28 Low Low
Emphysema 6 22.96 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we found that GC treatment induced an early suppression of MK protein expression at PN5, whereas RA treatment was associated with higher and persistent MK expression to PN10 in neonatal rats.
Negative_regulation (suppression) of Gene_expression (expression) of MK associated with rheumatoid arthritis
1) Confidence 0.29 Published 2009 Journal Respir Res Section Body Doc Link PMC2739515 Disease Relevance 0.64 Pain Relevance 0
DEX treatment of rat pups decreased, and RA treatment increased lung MK expression, whereas concurrent DEX+RA treatment prevented the DEX-induced decrease in MK expression.
Negative_regulation (prevented) of Gene_expression (expression) of MK in lung associated with rheumatoid arthritis and dexamethasone
2) Confidence 0.21 Published 2009 Journal Respir Res Section Abstract Doc Link PMC2739515 Disease Relevance 0.68 Pain Relevance 0.47
We hypothesized that MK expression in both lungs and in isolated AT2 cells would be decreased by corticosteroids and increased by RA.


Negative_regulation (decreased) of Gene_expression (expression) of MK in lungs associated with corticosteroid and rheumatoid arthritis
3) Confidence 0.21 Published 2009 Journal Respir Res Section Body Doc Link PMC2739515 Disease Relevance 0.64 Pain Relevance 0.12
LWG was responsible for the determination of MK expression in alveolar type II cells and fibroblasts.
Negative_regulation (determination) of Gene_expression (expression) of MK in fibroblasts
4) Confidence 0.21 Published 2009 Journal Respir Res Section Body Doc Link PMC2739515 Disease Relevance 0.05 Pain Relevance 0.03
Further, in the normal developing lung, MK expression increases from PN2, peaks at PN4, and decreases thereafter [8].
Negative_regulation (decreases) of Gene_expression (expression) of MK in lung
5) Confidence 0.19 Published 2009 Journal Respir Res Section Body Doc Link PMC2739515 Disease Relevance 0.67 Pain Relevance 0.26
The fact that GC treatment decreased MK expression both in vivo and in cultured type II lung epithelial cells, (as demonstrated by the current study), and also decreased Tie1 expression on PN10 and 15, suggests that GC might inhibit alveolarization by interfering with epithelial-endothelial communication via MK and altering normal alveolar septal vascular development.
Negative_regulation (decreased) of Gene_expression (expression) of MK in epithelial cells
6) Confidence 0.19 Published 2009 Journal Respir Res Section Body Doc Link PMC2739515 Disease Relevance 0.38 Pain Relevance 0.03

General Comments

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