INT281978

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.30
First Reported 2009
Last Reported 2009
Negated 0
Speculated 3
Reported most in Body
Documents 1
Total Number 13
Disease Relevance 5.90
Pain Relevance 2.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (MDK) signal transduction (MDK) extracellular region (MDK)
Anatomy Link Frequency
lung 4
epithelial cells 2
fibroblasts 2
MDK (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 624 99.84 Very High Very High Very High
corticosteroid 104 99.84 Very High Very High Very High
Inflammation 26 88.32 High High
ketamine 13 5.00 Very Low Very Low Very Low
anesthesia 13 5.00 Very Low Very Low Very Low
alcohol 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 598 99.68 Very High Very High Very High
Targeted Disruption 39 99.24 Very High Very High Very High
Hypoxia 13 95.16 Very High Very High Very High
Cancer 13 89.84 High High
INFLAMMATION 13 88.32 High High
Bronchopulmonary Dysplasia 117 86.08 High High
Pneumonia 13 73.76 Quite High
Infection 13 48.64 Quite Low
Hyperglycemia 13 47.76 Quite Low
Emphysema 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Through gene array analysis of GC receptor knockout mice, Kaplan et al demonstrated that MK is dynamically regulated by both GC and retinoic acid during normal fetal lung development [10].
Regulation (regulated) of MK in lung associated with targeted disruption
1) Confidence 0.30 Published 2009 Journal Respir Res Section Body Doc Link PMC2739515 Disease Relevance 0.39 Pain Relevance 0
In summary, we have demonstrated that MK is differentially regulated by corticosteroid and retinoid treatment during postnatal lung development, and that its expression matches the hormonal effects on alveolarization.
Regulation (regulated) of MK in lung associated with corticosteroid
2) Confidence 0.30 Published 2009 Journal Respir Res Section Body Doc Link PMC2739515 Disease Relevance 0.30 Pain Relevance 0.09
Collectively, our data suggest that MK is likely differentially regulated by GC and RA from the late saccular to early alveolar stage of lung development.
Regulation (regulated) of MK in lung associated with rheumatoid arthritis
3) Confidence 0.26 Published 2009 Journal Respir Res Section Body Doc Link PMC2739515 Disease Relevance 0.87 Pain Relevance 0.07
Western blot analysis of MK regulation in Type II-like cells and lung fibroblasts are shown in Figure 5.
Regulation (regulation) of MK in fibroblasts
4) Confidence 0.13 Published 2009 Journal Respir Res Section Body Doc Link PMC2739515 Disease Relevance 0.33 Pain Relevance 0.25
Lastly, we have previously shown that MK is upregulated in glucocorticoid receptor knockout mice, and that GC and RA differentially regulate MK in vitro [10].
Regulation (regulate) of MK associated with targeted disruption and rheumatoid arthritis
5) Confidence 0.13 Published 2009 Journal Respir Res Section Body Doc Link PMC2739515 Disease Relevance 0.71 Pain Relevance 0.12
We conclude that MK is expressed by AT2 cells, and is differentially regulated by corticosteroid and retinoid treatment in a manner consistent with hormonal effects on alveolarization during postnatal lung development.



Regulation (regulated) of MK in lung associated with corticosteroid
6) Confidence 0.13 Published 2009 Journal Respir Res Section Abstract Doc Link PMC2739515 Disease Relevance 0.62 Pain Relevance 0.48
We next examined the expression and hormonal regulations of MK in isolated human alveolar epithelial cells and fibroblasts.
Spec (examined) Regulation (regulations) of MK in fibroblasts
7) Confidence 0.13 Published 2009 Journal Respir Res Section Body Doc Link PMC2739515 Disease Relevance 0.32 Pain Relevance 0.28
However, in our hands, changes in steady state MK mRNA did not match MK protein expression after hormonal treatments.
Regulation (changes) of MK
8) Confidence 0.13 Published 2009 Journal Respir Res Section Body Doc Link PMC2739515 Disease Relevance 0.38 Pain Relevance 0.03
The mechanisms controlling this balance are largely unknown, but recent evidence suggests that midkine (MK) may function as a critical regulator.
Regulation (regulator) of midkine
9) Confidence 0.12 Published 2009 Journal Respir Res Section Body Doc Link PMC2739515 Disease Relevance 0.52 Pain Relevance 0.31
The purpose of this study was to examine regulation of MK by GC and RA during postnatal alveolar formation in rats.


Spec (examine) Regulation (regulation) of MK associated with rheumatoid arthritis
10) Confidence 0.12 Published 2009 Journal Respir Res Section Abstract Doc Link PMC2739515 Disease Relevance 0.30 Pain Relevance 0.19
The mechanisms controlling this balance are largely unknown, but recent evidence suggests that midkine (MK) may function as a critical regulator.
Regulation (regulator) of MK
11) Confidence 0.12 Published 2009 Journal Respir Res Section Body Doc Link PMC2739515 Disease Relevance 0.52 Pain Relevance 0.31
The angiogenic factor midkine is regulated by dexamethasone and retinoic acid during alveolarization and in alveolar epithelial cells

Background

Regulation (regulated) of midkine in epithelial cells associated with dexamethasone
12) Confidence 0.12 Published 2009 Journal Respir Res Section Title Doc Link PMC2739515 Disease Relevance 0.32 Pain Relevance 0.23
We next examined the expression and hormonal regulations of MK in isolated human alveolar epithelial cells and fibroblasts.
Spec (examined) Regulation (regulations) of MK in epithelial cells
13) Confidence 0.05 Published 2009 Journal Respir Res Section Body Doc Link PMC2739515 Disease Relevance 0.32 Pain Relevance 0.28

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox