INT28204

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Context Info
Confidence 0.45
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.12
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (F13A1) transferase activity, transferring acyl groups (F13A1) cytoplasm (F13A1)
Anatomy Link Frequency
plasma 2
brain 2
mononuclear cells 2
F13A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Demyelination 47 96.08 Very High Very High Very High
Inflammation 15 87.52 High High
palliative 2 81.32 Quite High
Pain 6 79.36 Quite High
cva 2 69.36 Quite High
Central nervous system 6 50.00 Quite Low
excitatory amino acid 1 40.16 Quite Low
Glutamate 3 30.80 Quite Low
Glutamate receptor 2 19.04 Low Low
Multiple sclerosis 25 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thrombosis 31 99.12 Very High Very High Very High
Fistula 6 98.68 Very High Very High Very High
Coagulation Disorder 2 97.30 Very High Very High Very High
Cancer 9 96.22 Very High Very High Very High
Demyelinating Disease 78 96.08 Very High Very High Very High
Neuromyelitis Optica 31 91.44 High High
Thrombophilia 1 91.40 High High
Sickle Cell Anemia 6 88.48 High High
INFLAMMATION 12 87.52 High High
Infection 1 86.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Experience in fibrin glue application for the treatment of non-formed fistulas of the gastrointestinal tract].
Positive_regulation ([Experience) of Localization (application) of fibrin associated with fistula
1) Confidence 0.45 Published 2006 Journal Khirurgiia (Mosk) Section Title Doc Link 17047628 Disease Relevance 0.43 Pain Relevance 0.08
Elevated plasma D-dimer levels indicate increased plasmin degradation of cross-linked fibrin, and are therefore an indirect indication of increased thrombin activity and fibrin formation.
Positive_regulation (increased) of Localization (formation) of fibrin in plasma
2) Confidence 0.05 Published 1989 Journal Haemostasis Section Abstract Doc Link 2731776 Disease Relevance 0.30 Pain Relevance 0.22
Tumor cells can either directly activate the blood clotting system or indirectly stimulate mononuclear cells to synthesize and express various procoagulants, subsequently leading to prothrombin activation, fibrin formation, and generation of a thrombus.
Positive_regulation (activation) of Localization (formation) of fibrin in mononuclear cells associated with coagulation disorder, cancer and thrombosis
3) Confidence 0.05 Published 1999 Journal Semin. Thromb. Hemost. Section Abstract Doc Link 10357083 Disease Relevance 1.76 Pain Relevance 0.13
We sought to determine where activated factor X (FXa), (pro)thrombin, and fibrin(ogen) are localized in thrombi formed under venous shear.


Positive_regulation (activated) of Localization (localized) of fibrin
4) Confidence 0.04 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2861630 Disease Relevance 0.06 Pain Relevance 0
Astrocyte dysfunction may impair blood–brain barrier function, leading to perivascular precipitation of fibrin.
Positive_regulation (leading) of Localization (precipitation) of fibrin in brain
5) Confidence 0.01 Published 2010 Journal Acta Neuropathol Section Body Doc Link PMC2892605 Disease Relevance 0.57 Pain Relevance 0.14

General Comments

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