INT28209

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Context Info
Confidence 0.58
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.36
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tbxa2r) plasma membrane (Tbxa2r) signal transducer activity (Tbxa2r)
Anatomy Link Frequency
plasma 2
myocardium 2
sympathetic nervous system 2
Tbxa2r (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 3 99.72 Very High Very High Very High
ischemia 8 99.64 Very High Very High Very High
epidural 1 99.50 Very High Very High Very High
antagonist 16 97.08 Very High Very High Very High
Inflammation 30 86.60 High High
Central nervous system 5 67.60 Quite High
agonist 33 53.28 Quite High
adenocard 75 50.00 Quite Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 2 Under Development 4 99.92 Very High Very High Very High
Cv Unclassified Under Development 8 99.64 Very High Very High Very High
Adult Respiratory Distress Syndrome 61 90.36 High High
Coronary Heart Disease 3 90.16 High High
INFLAMMATION 18 86.60 High High
Pneumonia 20 85.28 High High
Increased Venous Pressure Under Development 6 75.64 Quite High
Heart Rate Under Development 1 71.92 Quite High
Injury 12 50.08 Quite High
Stress 19 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our previous studies indicate that the blockade of the sympathetic nervous system by spinal anesthesia or epidural anesthesia inhibits the release of TXA2 induced by limb ischemia with thigh tourniquet in patients with lower limb surgery.
Positive_regulation (induced) of Localization (release) of TXA2 in sympathetic nervous system associated with anesthesia, ischemia and epidural
1) Confidence 0.58 Published 1989 Journal Masui Section Abstract Doc Link 2733138 Disease Relevance 0.17 Pain Relevance 0.34
H2O2 exposure induces translocation of functional thromboxane receptor to the plasma membrane
Positive_regulation (induces) of Localization (translocation) of thromboxane receptor in plasma
2) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939892 Disease Relevance 0 Pain Relevance 0.05
TXA2 release was markedly increased, as demonstrated by contraction of rabbit aortic strips perfused with coronary venous blood draining the ischemic myocardium, and by increased release of radioimmunologically assayable TXB2.
Positive_regulation (increased) of Localization (release) of TXA2 in myocardium
3) Confidence 0.35 Published 1984 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 6202970 Disease Relevance 0.58 Pain Relevance 0
Binding of LPS to A1 leads to increased secretion of interleukin-6 and thromboxane A2, which can be significantly reduced by administration of a selective A1 antagonist [44].
Positive_regulation (increased) of Localization (secretion) of thromboxane A2 associated with antagonist
4) Confidence 0.03 Published 2008 Journal Crit Care Section Body Doc Link PMC2592730 Disease Relevance 0.61 Pain Relevance 0.25

General Comments

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