INT28210

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Context Info
Confidence 0.49
First Reported 1989
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.09
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tbxa2r) plasma membrane (Tbxa2r) signal transducer activity (Tbxa2r)
Anatomy Link Frequency
platelet 6
sympathetic nervous system 2
Tbxa2r (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 3 99.98 Very High Very High Very High
epidural 1 99.76 Very High Very High Very High
ischemia 8 99.32 Very High Very High Very High
aspirin 257 99.20 Very High Very High Very High
antagonist 18 98.52 Very High Very High Very High
Inflammation 61 86.20 High High
Central nervous system 5 70.48 Quite High
adenocard 80 50.00 Quite Low
agonist 29 34.92 Quite Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 16 100.00 Very High Very High Very High
Cv Unclassified Under Development 8 99.32 Very High Very High Very High
Lifespan 2 98.68 Very High Very High Very High
Hypertension 3 96.36 Very High Very High Very High
Stress 9 94.88 High High
Adult Respiratory Distress Syndrome 61 89.96 High High
INFLAMMATION 58 86.20 High High
Pneumonia 20 84.88 Quite High
Diabetes Mellitus 144 80.88 Quite High
Disease 16 77.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our previous studies indicate that the blockade of the sympathetic nervous system by spinal anesthesia or epidural anesthesia inhibits the release of TXA2 induced by limb ischemia with thigh tourniquet in patients with lower limb surgery.
Negative_regulation (inhibits) of Localization (release) of TXA2 in sympathetic nervous system associated with anesthesia, ischemia and epidural
1) Confidence 0.49 Published 1989 Journal Masui Section Abstract Doc Link 2733138 Disease Relevance 0.17 Pain Relevance 0.34
As COX-1 inhibition by aspirin is irreversible, there is a cumulative inhibition of TXA2 generation by platelets when low doses of aspirin are administered chronically [5].
Negative_regulation (inhibition) of Localization (generation) of TXA2 in platelets associated with aspirin
2) Confidence 0.12 Published 2004 Journal Thromb J Section Body Doc Link PMC331420 Disease Relevance 0.06 Pain Relevance 0.39
There is a non-linear relationship between inhibition of platelet TXA2 generation and inhibition of TXA2-dependent platelet aggregation.
Negative_regulation (inhibition) of Localization (aggregation) of TXA2-dependent in platelet
3) Confidence 0.12 Published 2004 Journal Thromb J Section Body Doc Link PMC331420 Disease Relevance 0.13 Pain Relevance 0.45
ASA is more than 100 years old and provides marked benefits in the primary and secondary prevention of coronary, cerebral, and peripheral vascular disease.47 ASA inhibits TXA2 production by acetylating a serine residue at position 529 within the active site of the enzyme cyclo-oxygenase.48 Inhibition is irreversible and lasts for the lifespan of the platelet (7–10 days).49 The inhibition of TXA2 production prevents TXA2-mediated granule release and aggregation, while aggregation via thromboxane- independent mechanisms, such as that induced by thrombin or elevated shear stress, can still occur.
Negative_regulation (prevents) of Localization (release) of TXA2-mediated in platelet associated with stress, lifespan and increased venous pressure under development
4) Confidence 0.12 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2672443 Disease Relevance 0.91 Pain Relevance 0.08
DMTU reduced pulmonary vasoconstriction to U-46619 and protamine but not to TxA2 release, indicating that DMTU had unspecific vascular effects in group III.
Neg (not) Negative_regulation (reduced) of Localization (release) of TxA2 associated with increased venous pressure under development
5) Confidence 0.09 Published 1993 Journal J. Appl. Physiol. Section Abstract Doc Link 8335575 Disease Relevance 0.26 Pain Relevance 0.07
Binding of LPS to A1 leads to increased secretion of interleukin-6 and thromboxane A2, which can be significantly reduced by administration of a selective A1 antagonist [44].
Negative_regulation (reduced) of Localization (secretion) of thromboxane A2 associated with antagonist
6) Confidence 0.03 Published 2008 Journal Crit Care Section Body Doc Link PMC2592730 Disease Relevance 0.55 Pain Relevance 0.25

General Comments

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