INT28211

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Context Info
Confidence 0.44
First Reported 1982
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 1.73
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tbxa2r) signal transducer activity (Tbxa2r)
Anatomy Link Frequency
endothelial cells 2
aorta 2
endothelium 2
limb 2
Tbxa2r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 6 99.64 Very High Very High Very High
cva 24 95.76 Very High Very High Very High
anesthesia 7 95.52 Very High Very High Very High
epidural 2 94.96 High High
bradykinin 5 90.24 High High
antagonist 1 70.28 Quite High
agonist 9 5.00 Very Low Very Low Very Low
cerebral cortex 3 5.00 Very Low Very Low Very Low
Bioavailability 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 6 99.64 Very High Very High Very High
Cv General 4 Under Development 18 95.76 Very High Very High Very High
Increased Venous Pressure Under Development 27 95.48 Very High Very High Very High
Hypoxia 3 87.88 High High
Disease 6 79.28 Quite High
Hypersensitivity 15 68.64 Quite High
Hypertension 6 67.84 Quite High
Diabetes Mellitus 3 67.28 Quite High
Atherosclerosis 3 66.88 Quite High
Cv General 3 Under Development 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SQ 80,338 (10.0 micrograms/ml) prevented arachidonate-induced release of TXA2 from the isolated perfused guinea pig lung while SQ 24,775 (1.0 microgram/ml) antagonized the contraction of the isolated rat aorta induced by 9,11,AZO-PGH2.
Positive_regulation (induced) of Localization (release) of TXA2 in aorta
1) Confidence 0.44 Published 1982 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6807699 Disease Relevance 0 Pain Relevance 0.12
As noted above, the increased release of endogenous TXA2 can only partly explain our observations.
Positive_regulation (increased) of Localization (release) of TXA2
2) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013104 Disease Relevance 0.13 Pain Relevance 0
On the other hand, the cerebrovascular endothelium is not likely to be the only source of TXA2 release since L-NAME induced vasomotion in only 3 out of 32 isolated MCAs in vitro, suggesting that vascular TXA2 production by itself may not be sufficient to evoke vasomotion even in case of diminished NO synthesis.
Positive_regulation (source) of Localization (release) of TXA2 in endothelium
3) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013104 Disease Relevance 0.64 Pain Relevance 0.10
NO reportedly suppresses the synthesis of TXA2 [29] and inhibition of NOS was recently reported to enhance TXA2 release also from cerebrovascular endothelial cells [17].
Positive_regulation (enhance) of Localization (release) of TXA2 in endothelial cells
4) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013104 Disease Relevance 0.70 Pain Relevance 0.12
[The participation of the sympathetic nervous system in thromboxane A2 release induced by limb ischemia].
Positive_regulation (induced) of Localization (release) of thromboxane A2 in limb associated with ischemia
5) Confidence 0.02 Published 1989 Journal Masui Section Title Doc Link 2733138 Disease Relevance 0.26 Pain Relevance 0.37
CONCLUSION: Under combined general and epidural anesthesia arterial hypotension following MT due to endogenous PGI2 release is associated with enhanced release of AVP, active renin, epinephrine and thromboxane A2, presumably contributing to hemodynamic stability within 30 min after MT.


Positive_regulation (enhanced) of Localization (release) of thromboxane A2
6) Confidence 0.01 Published 1998 Journal Acta Anaesthesiol Scand Section Body Doc Link 9773140 Disease Relevance 0 Pain Relevance 0

General Comments

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