INT282129

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Context Info
Confidence 0.56
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 3.12
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il10, Icam1) extracellular region (Il10) cell adhesion (Icam1)
plasma membrane (Icam1) intracellular (Il10)
Anatomy Link Frequency
sciatic nerve 1
neural 1
Il10 (Mus musculus)
Icam1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 34 99.92 Very High Very High Very High
cytokine 30 97.24 Very High Very High Very High
Sciatic nerve 78 97.08 Very High Very High Very High
Demyelination 34 96.72 Very High Very High Very High
Spinal cord 32 5.00 Very Low Very Low Very Low
Neuritis 6 5.00 Very Low Very Low Very Low
Peripheral nervous system 6 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 6 100.00 Very High Very High Very High
INFLAMMATION 34 99.92 Very High Very High Very High
Neuropathy 14 99.92 Very High Very High Very High
Demyelinating Disease 44 99.32 Very High Very High Very High
Targeted Disruption 56 97.36 Very High Very High Very High
Paralysis 68 95.28 Very High Very High Very High
Encephalitis 2 94.68 High High
Death 20 94.24 High High
Muscle Weakness 2 94.12 High High
Systemic Lupus Erythematosus 2 93.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-10 upregulates ICAM-1 within neural tissues, promoting massive macrophage influx, inflammation-induced demyelination, and subsequent loss of neural tissue resulting in muscle weakness and paralysis.
IL-10 Positive_regulation (upregulates) of ICAM-1 in neural associated with demyelination, inflammation, muscle weakness and paralysis
1) Confidence 0.56 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2743195 Disease Relevance 1.71 Pain Relevance 0.25
IL-10 upregulates the adhesion molecules ICAM-1, that causes increased trafficking of inflammatory macrophages into the sciatic nerve via CD11b expressed on the macrophage surface, a receptor for the ligand ICAM-1[14].
IL-10 Positive_regulation (upregulates) of ICAM-1 in sciatic nerve associated with inflammation, sciatic nerve and adhesions
2) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743195 Disease Relevance 1.41 Pain Relevance 0.57

General Comments

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