INT282142

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.27
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Grm1, Trib3) nucleolus (Trib3) plasma membrane (Grm1)
enzyme binding (Trib3) kinase activity (Trib3) signal transducer activity (Grm1)
Grm1 (Rattus norvegicus)
Trib3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 14 100.00 Very High Very High Very High
Glutamate receptor 1 90.72 High High
Glutamate 26 84.44 Quite High
Central nervous system 5 83.96 Quite High
Dorsal horn 5 82.28 Quite High
Spinal cord 9 81.80 Quite High
medulla 13 76.20 Quite High
Thalamus 2 73.84 Quite High
parabrachial 1 72.68 Quite High
fifth nerve 1 41.76 Quite Low
Disease Link Frequency Relevance Heat
Nociception 7 78.96 Quite High
Pain 5 5.00 Very Low Very Low Very Low
Myelodysplastic Syndromes 2 5.00 Very Low Very Low Very Low
Depression 2 5.00 Very Low Very Low Very Low
Ganglion Cysts 2 5.00 Very Low Very Low Very Low
Decapitation 1 5.00 Very Low Very Low Very Low
Ketoacidosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Group I mGluRs (mGluR1 and 5) activate phospholipase C (PLC) via Gq-protein, resulting in phosphoinositide hydrolysis, Ca2+ release from inositol 1,4,5-triphosphate (IP3)-sensitive intracellular stores, and protein kinase C (PKC) activation by diacylglycerol (DAG) [12].
mGluR1 Positive_regulation (activate) of Positive_regulation (activation) of kinase associated with kinase c
1) Confidence 0.01 Published 2009 Journal Mol Pain Section Body Doc Link PMC2743647 Disease Relevance 0.27 Pain Relevance 0.57

General Comments

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