INT28216

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Context Info
Confidence 0.75
First Reported 1989
Last Reported 2010
Negated 2
Speculated 4
Reported most in Abstract
Documents 173
Total Number 177
Disease Relevance 93.97
Pain Relevance 20.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HRAS) signal transduction (HRAS) Golgi apparatus (HRAS)
plasma membrane (HRAS) nucleus (HRAS) GTPase activity (HRAS)
Anatomy Link Frequency
joints 6
synovium 6
pancreas 5
duct 4
NHEK 4
HRAS (Homo sapiens)
HRAS - G12V (2)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 3 99.96 Very High Very High Very High
Chronic pancreatitis 112 99.92 Very High Very High Very High
Nicotine 68 99.84 Very High Very High Very High
Osteoarthritis 868 99.76 Very High Very High Very High
Analgesic 53 99.12 Very High Very High Very High
Pain 584 99.04 Very High Very High Very High
Inflammation 309 98.88 Very High Very High Very High
Pyramidal cell 1 98.80 Very High Very High Very High
agonist 38 98.40 Very High Very High Very High
cytokine 130 98.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 436 100.00 Very High Very High Very High
Disease 401 100.00 Very High Very High Very High
Pancreatic Cancer 226 100.00 Very High Very High Very High
Adenocarcinoma 94 100.00 Very High Very High Very High
Injury 87 100.00 Very High Very High Very High
Sprains And Strains 525 99.98 Very High Very High Very High
Pancreatitis 157 99.92 Very High Very High Very High
Hyperplasia 152 99.84 Very High Very High Very High
Cirrhosis 134 99.84 Very High Very High Very High
Osteoarthritis 920 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At an early stage of AD, elevated expression of p21ras co-localizes with p16Ink4 in pyramidal neurons [213].
Gene_expression (expression) of p21ras in pyramidal neurons associated with pyramidal cell and disease
1) Confidence 0.75 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.90 Pain Relevance 0.05
We report that selective expression of an endogenous K-Ras(G12V) oncogene in embryonic cells of acinar/centroacinar lineage results in pancreatic intraepithelial neoplasias (PanINs) and invasive PDA, suggesting that PDA originates by differentiation of acinar/centroacinar cells or their precursors into ductal-like cells.
Gene_expression (expression) of K-Ras (G12V) in embryonic cells associated with adenocarcinoma
2) Confidence 0.75 Published 2007 Journal Cancer Cell Section Abstract Doc Link 17349585 Disease Relevance 0.83 Pain Relevance 0.14
In patients with pancreatic carcinoma (PC), K-ras mutations were detected in 14 of 23 (60.9%) in DLF 1, 16 of 21 (76.2%) in DLF 2, 14 of 20 (70.0%) in PPJ, and 19 of 21 (90.5%) in either DLF 1 or DLF 2.
Gene_expression (detected) of K-ras associated with pancreatic cancer
3) Confidence 0.75 Published 1999 Journal Pancreas Section Abstract Doc Link 10090410 Disease Relevance 0.53 Pain Relevance 0.08
A 24-h treatment with DFMO caused a dose-dependent decrease in the colony-forming ability of cells expressing an activated K-ras but had no effect on the viability of the parental Caco-2 cells.
Gene_expression (expressing) of K-ras in Caco-2
4) Confidence 0.75 Published 2000 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 11097222 Disease Relevance 0.65 Pain Relevance 0.05
METHODS: We examined expression of Ki-67, CEA, p53, and K-ras, in the surgical specimens of pancreas with adenocarcinomas (n=11) and chronic pancreatitis (n=12).
Spec (examined) Gene_expression (expression) of K-ras in pancreas
5) Confidence 0.75 Published 2005 Journal World J. Gastroenterol. Section Body Doc Link 16425381 Disease Relevance 0.29 Pain Relevance 0
In cases with chronic pancreatitis, the specimen was pathologically examined as in cases with pancreas cancer, and they were also determined as normal (n=10), ductal hyperplasia (n=4), or dysplasia (n=5). p53 and K-ras expression were also studied by immunohistochemical staining.
Gene_expression (expression) of K-ras in pancreas
6) Confidence 0.75 Published 2005 Journal World J. Gastroenterol. Section Body Doc Link 16425381 Disease Relevance 0.21 Pain Relevance 0
K-ras mutations can be detected in cancer tissue and pancreatic duct secretions.
Gene_expression (detected) of K-ras in pancreatic duct associated with cancer
7) Confidence 0.75 Published 1999 Journal Ann. Oncol. Section Abstract Doc Link 10436800 Disease Relevance 1.26 Pain Relevance 0.04
Expression of Ki-67, p53, and K-ras in chronic pancreatitis and pancreatic ductal adenocarcinoma.
Gene_expression (Expression) of K-ras associated with adenocarcinoma and chronic pancreatitis
8) Confidence 0.75 Published 2005 Journal World J. Gastroenterol. Section Title Doc Link 16425381 Disease Relevance 0.39 Pain Relevance 0.20
Although mutant (mt) K-ras can be detected in the pancreatic juice of most patients with pancreatic cancer, it is also present in patients with non-inherited chronic pancreatitis who do not progress to pancreatic cancer (at least in the short to medium term), as well as increasingly in the older population without pancreatic disease.
Gene_expression (detected) of K-ras associated with pancreatitis, pancreatic cancer and chronic pancreatitis
9) Confidence 0.75 Published 2001 Journal Pancreatology Section Abstract Doc Link 12120229 Disease Relevance 1.44 Pain Relevance 0.37
Since a formal tissue diagnosis may be difficult to establish in pancreatic cancer, detection of K-ras in these materials is an attractive approach to diagnosis.
Gene_expression (detection) of K-ras associated with pancreatic cancer
10) Confidence 0.75 Published 2001 Journal Eur J Gastroenterol Hepatol Section Abstract Doc Link 11711767 Disease Relevance 0.42 Pain Relevance 0.16
Immunohistochemical evaluation of K-ras, p53, and HER-2/neu expression in hyperplastic, dysplastic, and carcinomatous lesions of the pancreas: evidence for multistep carcinogenesis.
Gene_expression (expression) of K-ras in pancreas associated with hyperplasia
11) Confidence 0.75 Published 1999 Journal Hum. Pathol. Section Title Doc Link 10029438 Disease Relevance 0.77 Pain Relevance 0.07
Also, agents such as perillyl alcohol and lovastatin that interfere with protein isoprenylation and, hence, inhibit oncogene activation may protect against aberrant K-ras expression.
Gene_expression (expression) of K-ras associated with alcohol
12) Confidence 0.75 Published 1995 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 8672984 Disease Relevance 0.42 Pain Relevance 0.14
On the other hand, K-ras mutations were negative in PJ from chronic pancreatitis with one exception by PCR-RFLP method.
Neg (negative) Gene_expression (negative) of K-ras associated with chronic pancreatitis
13) Confidence 0.75 Published 1995 Journal Nippon Rinsho Section Abstract Doc Link 7699881 Disease Relevance 0.83 Pain Relevance 0.10
Immunohistochemically, most tumor cells were positive for neuron specific enolase, synaptophysin, alpha-1-antitrypsin and vimentin and sometimes for the estrogen receptor related antigen, ER-D5, and the oncogen product of c-Ha-ras, c-Ha-ras P21.
Gene_expression (product) of c-Ha-ras in neuron associated with cancer
14) Confidence 0.75 Published 1989 Journal Jpn. J. Clin. Oncol. Section Abstract Doc Link 2733163 Disease Relevance 0.84 Pain Relevance 0.08
However, the earliest stage in which K-ras mutations can be detected in potential precursor lesions of pancreatic cancer remains unclear.
Gene_expression (detected) of K-ras associated with pancreatic cancer
15) Confidence 0.75 Published 1997 Journal Surgery Section Abstract Doc Link 9001550 Disease Relevance 0.53 Pain Relevance 0.16
Point mutations in K-ras and p53 genes, and expression of p53 protein.
Gene_expression (expression) of K-ras
16) Confidence 0.75 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247607 Disease Relevance 0.10 Pain Relevance 0
Studies of cancers of the pancreas and breast have shown that OCs may interact with genetic alterations in tumors such as K-ras mutations or p53 overexpression (Hoyer et al. 2002; Porta et al. 1999; Slebos et al. 2000).
Gene_expression (overexpression) of K-ras in pancreas associated with cancer
17) Confidence 0.75 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247607 Disease Relevance 0.76 Pain Relevance 0
K-ras point mutation, telomerase activity, and p53 overexpression were analyzed using mutant allele specific amplification, the telomeric repeat amplification protocol, and immunohistochemical staining, respectively.
Gene_expression (overexpression) of K-ras
18) Confidence 0.65 Published 2003 Journal Oncol. Rep. Section Abstract Doc Link 12579258 Disease Relevance 0.96 Pain Relevance 0.10
The tumor did not show somatic mutation of the APC and K-ras genes, which is a critical step for the adenoma-carcinoma sequence in colon cancer.
Gene_expression (mutation) of K-ras in colon associated with adenoma, cancer, colon cancer and carcinoma
19) Confidence 0.65 Published 2002 Journal J. Gastroenterol. Section Abstract Doc Link 12051537 Disease Relevance 1.60 Pain Relevance 0.08
In pancreatic cancer, tobacco smoke can induced k-ras gene mutation and p16 and ppENK gene methylation [28,29].
Gene_expression (mutation) of k-ras associated with nicotine addiction and pancreatic cancer
20) Confidence 0.65 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2862018 Disease Relevance 1.93 Pain Relevance 0.10

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