INT282270

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.57
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 3.53
Pain Relevance 2.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Cav2) mitochondrion organization (Cav2) intracellular (Cav2)
protein complex (Cav2) cytoplasm (Cav2) cytosol (Cav2)
Anatomy Link Frequency
neurons 4
sensory neurons 1
colon 1
oocytes 1
Cav2 (Mus musculus)
Pain Link Frequency Relevance Heat
Trigeminal ganglion neurons 40 99.72 Very High Very High Very High
Pain 152 99.16 Very High Very High Very High
Calcium channel 36 96.12 Very High Very High Very High
imagery 33 92.48 High High
Migraine 144 90.40 High High
spinal dorsal horn 8 89.20 High High
qutenza 40 86.28 High High
agonist 86 85.88 High High
antagonist 19 81.76 Quite High
Calcitonin gene-related peptide 23 79.96 Quite High
Disease Link Frequency Relevance Heat
Adenocarcinoma 5 99.88 Very High Very High Very High
Ganglion Cysts 120 99.56 Very High Very High Very High
Pain 163 99.16 Very High Very High Very High
Adenoma 3 98.12 Very High Very High Very High
Carcinoma 2 97.60 Very High Very High Very High
Cancer 56 95.60 Very High Very High Very High
Injury 29 93.92 High High
Migraine Disorders 104 90.40 High High
Nociception 26 72.72 Quite High
Nervous System Injury 16 72.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intriguingly, SNL-induced enhancements of GFAP- and Iba 1-IR were markedly suppressed in Cav2.2-/- mice (Figure 2Cii, 2Ciii, 2D and 2E).
Gene_expression (suppressed) of Cav2
1) Confidence 0.57 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.50 Pain Relevance 0.30
We found that DHPG application upregulated barium currents in oocytes expressing mGluR5 and Cav2.3 but not mGluR5 and Cav3.2, suggesting subunit selective modulation of R-type, but not T-type, calcium channels by mGluR5 activation with DHPG (Figure 9C and 9D).
Neg (not) Gene_expression (expressing) of Cav2 in oocytes associated with calcium channel
2) Confidence 0.47 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2982802 Disease Relevance 0.18 Pain Relevance 0.13
The cDNAs for the Cav3.2 (accession number AF051946), Cav2.3 (L27745), ?
Gene_expression (cDNAs) of Cav2
3) Confidence 0.47 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2982802 Disease Relevance 0 Pain Relevance 0.03
We showed that a subpopulation of P2X3 expressing neurons also expressed CaV2.1 channels, thus providing ample opportunity for their crosstalk.
Gene_expression (expressed) of CaV2 in neurons
4) Confidence 0.46 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0.18 Pain Relevance 0.43
For immunofluorescence microscopy, the following antibodies were used: anti-P2X3, anti-P2X2, anti-TRPV1 and anti-CaV2.1 ?
Gene_expression (anti) of CaV2
5) Confidence 0.40 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0.13 Pain Relevance 0
For immunofluorescence microscopy, the following antibodies were used: anti-P2X3, anti-P2X2, anti-TRPV1 and anti-CaV2.1 ?
Gene_expression (anti) of CaV2
6) Confidence 0.40 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0.13 Pain Relevance 0
We also confirmed that CaV2.1 ?
Gene_expression (confirmed) of CaV2
7) Confidence 0.40 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0.29 Pain Relevance 0.09
Although significant, this difference was not very large probably because the number of P2X3 receptor expressing neurons that also expressed CaV2.1 channels was less than 50% of the total population whose contribution diluted the overall change (see Fig. 3F).
Gene_expression (expressed) of CaV2 in neurons
8) Confidence 0.35 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0 Pain Relevance 0
The main finding of the present study is the novel report of the phenotype of trigeminal ganglion neurons from KI mice expressing a CaV2.1 ?
Gene_expression (expressing) of CaV2 in neurons associated with ganglion cysts and trigeminal ganglion neurons
9) Confidence 0.35 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0.29 Pain Relevance 0.17
We set out to study whether such changes in P2X3 receptor function were indeed attributable to the gain of function of R192Q-mutated CaV2.1 Ca2+ channels in trigeminal neurons.
Gene_expression (channels) of CaV2 in neurons
10) Confidence 0.34 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0.19 Pain Relevance 0.44
Since CaV2.1 Ca2+ channels normally are expressed by trigeminal sensory neurons and contribute by approximately 40% to voltage-gated Ca2+ influx [17], we assessed whether the R192Q mutation might introduce a cascade of Ca2+-dependent signals controlling expression and function of the main pain receptors P2X3 and TRPV1 [18-21].
Gene_expression (expressed) of CaV2 in sensory neurons associated with pain
11) Confidence 0.31 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 1.24 Pain Relevance 1.11
While, the expression of caveolin-1 is elevated in a majority of the colon adenocarcinomas, the expression of caveolin-2 is undetectable in either normal colonocytes, adenomas, or carcinomas (Fine et al. 2001; Patlolla et al. 2004).
Gene_expression (expression) of caveolin-2 in colon associated with adenoma, adenocarcinoma and carcinoma
12) Confidence 0.07 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2745153 Disease Relevance 0.39 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox