INT282271

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Context Info
Confidence 0.12
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.44
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Hmgcr) embryo development (Hmgcr)
Hmgcr (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 14 88.40 High High
cINOD 7 5.00 Very Low Very Low Very Low
COX-2 inhibitor 6 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
aspirin 3 5.00 Very Low Very Low Very Low
Inflammatory stimuli 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Bile 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 33 98.44 Very High Very High Very High
Cancer 56 94.92 High High
INFLAMMATION 17 88.40 High High
Colorectal Cancer 1 76.32 Quite High
Carcinoma 2 71.12 Quite High
Adenoma 3 70.56 Quite High
Polyps 3 69.32 Quite High
Breast Cancer 3 64.64 Quite High
Coronary Artery Disease 1 55.04 Quite High
Rectal Cancer 1 50.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The current review will focus on the upregulation of COX-2 and HMG-CoA reductase enzymes and the signaling cascades that are altered as a result of this up-regulation.
Positive_regulation (upregulation) of Regulation (regulation) of HMG-CoA reductase
1) Confidence 0.12 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2745153 Disease Relevance 1.44 Pain Relevance 0.04

General Comments

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