INT282287

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.99
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cpox, Hmgcr) mitochondrion (Cpox) embryo development (Hmgcr)
cytoplasm (Cpox)
Anatomy Link Frequency
colon 1
Cpox (Mus musculus)
Hmgcr (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 14 5.00 Very Low Very Low Very Low
cINOD 7 5.00 Very Low Very Low Very Low
COX-2 inhibitor 6 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
aspirin 3 5.00 Very Low Very Low Very Low
Inflammatory stimuli 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Bile 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Polyps 3 99.92 Very High Very High Very High
Aberrant Crypt Foci 2 99.70 Very High Very High Very High
Colon Cancer 33 98.10 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 95.16 Very High Very High Very High
Breast Cancer 3 94.80 High High
Cancer 56 88.48 High High
INFLAMMATION 17 5.00 Very Low Very Low Very Low
Apoptosis 8 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 5 5.00 Very Low Very Low Very Low
Adenocarcinoma 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In colon cancer, the formation and progression of precancerous lesions like aberrant crypt foci and polyps is associated with the up-regulation of cycloxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS) and hydroxy methyl glutaryl CoA reductase (HMG-CoA reductase).
COX Binding (associated) of hydroxy methyl glutaryl CoA reductase in colon associated with aberrant crypt foci, colon cancer and polyps
1) Confidence 0.01 Published 2008 Journal Gene Regulation and Systems Biology Section Abstract Doc Link PMC2745153 Disease Relevance 0.99 Pain Relevance 0

General Comments

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