INT28235

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Context Info
Confidence 0.38
First Reported 1988
Last Reported 1997
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.73
Pain Relevance 2.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Cck, Gast) signal transduction (Gast) extracellular space (Cck)
Anatomy Link Frequency
CER 2
portal vein 1
CNS 1
Cck (Rattus norvegicus)
Gast (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cholecystokinin 51 100.00 Very High Very High Very High
Central nervous system 6 100.00 Very High Very High Very High
antagonist 3 99.60 Very High Very High Very High
Dopamine 1 76.32 Quite High
analgesia 1 75.76 Quite High
opiate 2 75.00 Quite High
Enkephalin 2 75.00 Quite High
Neuropeptide 5 63.48 Quite High
tetrodotoxin 1 62.64 Quite High
qutenza 1 61.28 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 1 95.28 Very High Very High Very High
Gallbladder Disease 3 94.88 High High
Bardet-biedl Syndrome 4 93.52 High High
Anxiety Disorder 1 75.32 Quite High
Disease 1 56.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunoreactive peptides released into the portal vein effluent were measured with three antisera that were relatively CCK specific, gastrin specific, and cross-reactive to both CCK and gastrin, respectively.
CCK Binding (cross-reactive) of gastrin in portal vein associated with cholecystokinin
1) Confidence 0.38 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2735417 Disease Relevance 0.23 Pain Relevance 0.34
While there is a clear role for vagal cholecystokininA receptors, the function of vagal afferent gastrin-cholecystokininB receptors remains to be determined.
cholecystokininA Spec (clear) Binding (role) of gastrin
2) Confidence 0.16 Published 1997 Journal Neuroscience Section Abstract Doc Link 9219953 Disease Relevance 0.19 Pain Relevance 0.12
In contrast, two other very similar peptides, the last four residues of CCK (CCK-4) whose sequence is Trp-Met-Asp-Phe-NH2, and the carboxyl terminal hexapeptide of little gastrin (LGA-6, Tyr-Gly-Trp-Met-Asp-Phe-NH2, i.e., residue 2 deleted relative to CCK-7 and CER-7 sequences), interact specifically with gastrin receptors and not at all or very weakly with peripheral receptors.
CCK Binding (interact) of gastrin in CER associated with cholecystokinin
3) Confidence 0.03 Published 1988 Journal Peptides Section Abstract Doc Link 2856638 Disease Relevance 0.09 Pain Relevance 0.64
In contrast, two other very similar peptides, the last four residues of CCK (CCK-4) whose sequence is Trp-Met-Asp-Phe-NH2, and the carboxyl terminal hexapeptide of little gastrin (LGA-6, Tyr-Gly-Trp-Met-Asp-Phe-NH2, i.e., residue 2 deleted relative to CCK-7 and CER-7 sequences), interact specifically with gastrin receptors and not at all or very weakly with peripheral receptors.
CCK Binding (interact) of gastrin in CER associated with cholecystokinin
4) Confidence 0.03 Published 1988 Journal Peptides Section Abstract Doc Link 2856638 Disease Relevance 0.09 Pain Relevance 0.63
CCK-AR, found predominantly in the GI system and select areas of the CNS, have high affinity for CCK and the nonpeptide antagonist L-364,718, whereas CCK-BR, found predominantly in the CNS and select areas of the GI system, have high affinity for CCK and gastrin and the nonpeptide antagonist L-365,260.
CCK Binding (affinity) of gastrin in CNS associated with antagonist, central nervous system and cholecystokinin
5) Confidence 0.02 Published 1995 Journal Am. J. Physiol. Section Abstract Doc Link 7491953 Disease Relevance 0.13 Pain Relevance 1.23

General Comments

This test has worked.

Literature

Doc ID Doc Source Reference Unique Pain Interactions Unique Single Events Pain Relevance
1 Medline Fleischer et al. (2008) 54 23 40.6
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